Mechanism and clinical role of TIMP-2 and IGFBP-7 in cardiac surgery-associated acute kidney injury: A review

作者全名：Leng, Jiajie; Li, Letai; Tu, Hongwen; Luo, Yuxiang; Cao, Zhenrui; Zhou, Kun; Rizvi, Syed M. Musa; Tie, Hongtao; Jiang, Yingjiu

作者地址：[Leng, Jiajie; Tu, Hongwen; Luo, Yuxiang; Cao, Zhenrui; Zhou, Kun; Rizvi, Syed M. Musa; Tie, Hongtao; Jiang, Yingjiu] Chongqing Med Univ, Dept Cardiothorac Surg, Affiliated Hosp 1, Chongqing 400001, Peoples R China; [Li, Letai] Chongqing Med Univ, Coll Clin Med 1, Dept Anesthesiol, Chongqing, Peoples R China

通信作者：Tie, HT (通讯作者)，Chongqing Med Univ, Dept Cardiothorac Surg, Affiliated Hosp 1, Chongqing 400001, Peoples R China.

来源：MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001230616700045

JCR分区：Q2

影响因子：1.3

年份：2024

卷号：103

期号：21

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结束页：　

文献类型：Article

关键词：acute kidney injury; biomarkers; cardiac surgery; insulin-like growth factor-binding protein-7; tissue inhibitor of metalloproteinase-2

摘要：Acute kidney injury (AKI) is a common postoperative complication, but there is still a lack of accurate biomarkers. Cardiac surgery-associated AKI is the most common cause of major-surgery-related AKI, and patients requiring renal replacement therapy have high mortality rates. Early diagnosis, intervention, and management are crucial for improving patient prognosis. However, diagnosing AKI based solely on changes in serum creatinine level and urine output is insufficient, as these changes often lag behind actual kidney damage, making early detection challenging. Biomarkers such as tissue inhibitor of metalloproteinases-2 (TIMP-2) and insulin-like growth factor-binding protein-7 (IGFBP-7) have been found to be significant predictors of moderate-to-severe AKI when combined with urine content analysis. This article reviews the mechanism of biomarkers TIMP-2 and IGFBP-7 in AKI and provides a comprehensive overview of the clinical effects of TIMP-2 and IGFBP-7 in cardiac surgery-associated AKI, including prediction, diagnosis, and progression.

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