Anthracycline-induced arrhythmias in breast cancer therapy: A meta-analysis of single-arm trials

作者全名：Ran, Tao; Chen, Jinyao; She, Qiurui; Mu, Yi; Zhang, Min; Mao, Min; Zuo, Zhong; Li, Juan

作者地址：[Ran, Tao; Mao, Min; Zuo, Zhong] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 1, Chongqing, Peoples R China; [Chen, Jinyao; She, Qiurui; Mu, Yi] Chongqing Med Univ, Sch Clin Med Coll 1, Chongqing, Peoples R China; [Zhang, Min] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China; [Li, Juan] Chongqing Med Univ, Dept Acad Affairs, Affiliated Hosp 1, Chongqing, Peoples R China

通信作者：Li, J (通讯作者)，Chongqing Med Univ, Dept Acad Affairs, Affiliated Hosp 1, Chongqing, Peoples R China.

来源：PLOS ONE

ESI学科分类：Multidisciplinary

WOS号：WOS:001231237700004

JCR分区：Q1

影响因子：2.9

年份：2024

卷号：19

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要：Introduction As of 2020, breast cancer has emerged as the predominant cause of cancer incidence globally. Anthracycline-based chemotherapy serves as a crucial element in the treatment regimen for breast cancer. However, these anthracycline-based drugs are associated with cardiac toxicity. This study represents the first clinical quantitative analysis aimed at accurately determining the incidences of arrhythmia and abnormal electrocardiogram (ECG) changes, thereby providing valuable data to bolster clinical drug usage and monitoring.Methods A systematic search was conducted across multiple databases including CNKI, VIP, Wanfang, PubMed, Embase, Web of Science, and the Cochrane Library. The incidence of combined arrhythmias in breast cancer patients and the associated heterogeneity were calculated using either a random effect model or a fixed effect model. Statistical analysis was performed using STATA16.Results The study encompassed a total of 37 articles, which included 5705 breast cancer patients undergoing anthracycline treatment. Among these patients, 2257 developed arrhythmias. The meta-analysis revealed that the incidence of anthracycline-associated arrhythmias and abnormal ECG changes in breast cancer patients was 0.41 (0.37, 0.44). Subgroup analysis indicated that the incidence of ST-T segment change was 0.19 (0.15, 0.23), the incidence of conduction block was 0.04 (0.02, 0.05), the incidence of premature beats was 0.09 (0.07, 0.11), and the incidence of atrial fibrillation was 0.04 (0.00, 0.12). Additional results are presented in Table 3.Conclusion This pioneering study accurately assesses the incidence of arrhythmias in breast cancer patients treated with anthracyclines. The findings provide clinicians with valuable insights into understanding and managing the cardiac toxicity associated with such treatment. Moreover, this study lays the foundation for future research exploring the mechanisms underlying these arrhythmias and potential preventative strategies.

基金机构：Natural Science Foundation of Chongqing [cstc2020jcyj-msxmX0853, cstc2021jcyj-msxmX0077]; Joint Medical Research Project of Chongqing Municipal Science and Health Commission [2020MSXM094]; Chongqing Science and Health Joint Medical Research Project [2018ZDXM010]

基金资助正文：This work was supported by the Natural Science Foundation of Chongqing (No. cstc2020jcyj-msxmX0853) , the Joint Medical Research Project of Chongqing Municipal Science and Health Commission (No.2020MSXM094), the Natural Science Foundation of Chongqing (No. cstc2021jcyj-msxmX0077). And the Chongqing Science and Health Joint Medical Research Project (2018ZDXM010). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.