Association of Metal Exposure with Novel Immunoinflammatory Indicators

作者全名：Zhao, Lingxiao; Chen, Xieyi; Chen, Zhongwen; Yang, Cantao; Huang, Qiang; Cheng, Shuqun

作者地址：[Zhao, Lingxiao; Chen, Xieyi; Chen, Zhongwen; Cheng, Shuqun] Chongqing Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Yixueyuan Rd, Chongqing 400016, Peoples R China; [Yang, Cantao] Yubei Dist Ctr Dis Control & Prevent, Chongqing 401120, Peoples R China; [Huang, Qiang] Chongqing Ctr Dis Control & Prevent, Chongqing 400707, Peoples R China

通信作者：Cheng, SQ (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth, Yixueyuan Rd, Chongqing 400016, Peoples R China.

来源：TOXICS

ESI学科分类：　

WOS号：WOS:001231553300001

JCR分区：Q1

影响因子：3.9

年份：2024

卷号：12

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：metals; inflammation; national health and nutrition examination survey; gender; inflammatory index

摘要：Objective: We aimed to investigate the relationship between metal exposure and novel immunoinflammatory indicators. Methods: Data on adults participating in the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2018 were analyzed. Various statistical models were employed to assess the association between metal exposure and novel immune-inflammation-related indicators. Additionally, the impact of metal exposure on inflammation in different gender populations was explored. Results: This study included 4482 participants, of whom 51.1% were male. Significant correlations were observed among various metals. Both elastic net (ENET) and linear regression models revealed robust associations between cadmium (Cd), cobalt (Co), arsenic (As), mercury (Hg), and immunoinflammatory indicators. Weighted quantile sum (WQS) and Quantile g-computation (Q-gcomp) models demonstrated strong associations between barium (Ba), Co, and Hg and immunoinflammatory indicators. Bayesian kernel machine regression (BKMR) analysis indicated an overall positive correlation between in vivo urinary metal levels and systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI). Furthermore, Co, As, and Hg emerged as key metals contributing to changes in novel immunoinflammatory indicators. Conclusions: Metals exhibit associations with emerging immunoinflammatory indicators, and concurrent exposure to mixed metals may exacerbate the inflammatory response. Furthermore, this relationship varies across gender populations.

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