A potential antiviral role for CCR5+CD8+T cells in children with hepatitis B
作者全名：Tan, Aoxue; He, Yi; Zhou, Yingzhi; Peng, Xiaorong; Chang, Yunan; Peng, Mingli; Ren, Hong; Xu, Hongmei
作者地址：[Tan, Aoxue; He, Yi; Zhou, Yingzhi; Peng, Xiaorong; Chang, Yunan; Xu, Hongmei] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Infect Dis,Chongqing Key Lab Child Infect & I, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China; [Peng, Mingli; Ren, Hong] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, 288 Tianwen Ave, Chongqing 401336, Peoples R China
通信作者：Xu, HM (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Infect Dis,Chongqing Key Lab Child Infect & I, 136 Zhongshan 2nd Rd, Chongqing 400014, Peoples R China.; Ren, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Dept Infect Dis,Key Lab Mol Biol Infect Dis,Minist, 288 Tianwen Ave, Chongqing 401336, Peoples R China.
来源：JOURNAL OF MEDICAL VIROLOGY
ESI学科分类：MICROBIOLOGY
WOS号：WOS:001232031300001
JCR分区：Q1
影响因子：6.8
年份：2024
卷号：96
期号：5
开始页：
结束页：
文献类型：Article
关键词：CD8; children; chronic hepatitis B; flow cytometry; hepatitis B virus; T cells
摘要：While dysfunctional exhausted CD8+ T cells hamper viral control when children acquire hepatitis B virus (HBV) infection, it's crucial to recognize that CD8+ T cells have diverse phenotypes and functions. This study explored a subset of CD8+ T cells expressing C-C chemokine receptor type 5 (CCR5) in children with HBV infection. Thirty-six patients in the immune tolerant group, 33 patients in the immune active group, 55 patients in the combined response group, and 22 healthy control children were enrolled. The frequency, functional molecules, and effector functions of the CCR5+CD8+ T cell population in different groups were evaluated. The frequency of CCR5+CD8+ T cells correlated positively with the frequency of CCR5+CD4+ T cells and patient age, and it correlated negatively with alanine aminotransferase, aspartate transaminase, HBV DNA, hepatitis B surface antigen, and lactic dehydrogenase levels. CCR5+CD8+ T cells had higher levels of inhibitory and activated receptors and produced higher levels of IFN-gamma, IL-2, and TNF-alpha than CCR5-CD8+ T cells. CCR5+CD8+ T cells were partially exhausted but possessed a stronger antiviral activity than CCR5-CD8+ T cells. The identification of this subset increases our understanding of CD8+ T cell functions and serves as a potential immunotherapeutic target for children with HBV infection.
基金机构：Second Affiliated Hospital of Chongqing Medical University; First batch of Key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China
基金资助正文：This work was supported by the Remarkable Innovation-Clinical Research Project, The Second Affiliated Hospital of Chongqing Medical University, and The First batch of Key Disciplines on Public Health in Chongqing, Health Commission of Chongqing, China.
