Targeting CD8+T cells with natural products for tumor therapy: Revealing insights into the mechanisms

作者全名：Wang, Yuke; Zeng, Yan; Yang, Wenyong; Wang, Xiuxuan; Jiang, Jingwen

作者地址：[Wang, Yuke; Zeng, Yan; Jiang, Jingwen] Sichuan Univ, West China Hosp, West China Sch Publ Hlth, State Key Lab Biotherapy, Chengdu 610041, Peoples R China; [Wang, Yuke; Zeng, Yan; Jiang, Jingwen] Sichuan Univ, West China Hosp, West China Hosp 4, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China; [Wang, Yuke; Zeng, Yan; Jiang, Jingwen] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China; [Wang, Yuke; Zeng, Yan; Jiang, Jingwen] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China; [Wang, Yuke; Yang, Wenyong] Chongqing Med Univ, Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Dept Neurosurg,Med Res Ctr,Affiliated Hosp,Chengdu, Chengdu, Peoples R China; [Wang, Xiuxuan] Beijing DCTY Biotech Co Ltd, Res & Dev Dept, Beijing, Peoples R China

通信作者：Jiang, JW (通讯作者)，Sichuan Univ, West China Hosp, West China Sch Publ Hlth, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.; Jiang, JW (通讯作者)，Sichuan Univ, West China Hosp, West China Hosp 4, West China Sch Basic Med Sci & Forens Med, Chengdu 610041, Peoples R China.; Jiang, JW (通讯作者)，Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.; Jiang, JW (通讯作者)，Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China.

来源：PHYTOMEDICINE

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:001232474800001

JCR分区：Q1

影响因子：6.7

年份：2024

卷号：129

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：Natural products; CD8+T cells; Anti -tumor effects; TCR; Co -stimulation; Inflammatory cytokine

摘要：Background: Despite significant advances in cancer immunotherapy over the past decades, such as T cellengaging chimeric antigen receptor (CAR) -T cell therapy and immune checkpoint blockade (ICB), therapeutic failure resulting from various factors remains prevalent. Therefore, developing combinational immunotherapeutic strategies is of great significance for improving the clinical outcome of cancer immunotherapy. Natural products are substances that naturally exist in various living organisms with multiple pharmacological or biological activities, and some of them have been found to have anti -tumor potential. Notably, emerging evidences have suggested that several natural compounds may boost the anti -tumor effects through activating immune response of hosts, in which CD8 + T cells play a pivotal role. Methods: The data of this review come from PubMed, Web of Science, Google Scholar, and ClinicalTrials (https:// clinicaltrials.gov/) with the keywords "CD8 + T cell", "anti -tumor", "immunity", "signal 1", "signal 2", "signal 3", "natural products", "T cell receptor (TCR)", "co -stimulation", "co -inhibition", "immune checkpoint", "inflammatory cytokine", "hesperidin", "ginsenoside", "quercetin", "curcumin", "apigenin", "dendrobium officinale polysaccharides (DOPS)", "luteolin", "shikonin", "licochalcone A", "erianin", "resveratrol", "procyanidin", "berberine", "usnic acid", "naringenin", "6-gingerol", "ganoderma lucidum polysaccharide (GL -PS)", "neem leaf

基金机构：Chinese NSFC [82373336, 82303238]; Sichuan Science and Technology Department [2024NSFSC2497, 2023NSFSC0667]; Third People's Hospital of Chengdu Clinical Research Program [CSY-YN-01-2023-013, CSY-YN-01-2023-005]; Sichuan University "From 0 to 1" Innovative Research Project [2023SCUH0024]

基金资助正文：This research was funded by Chinese NSFC (82373336, 82303238) and Sichuan Science and Technology Department (2024NSFSC2497, 2023NSFSC0667), The Third People's Hospital of Chengdu Clinical Research Program (CSY-YN-01-2023-013, CSY-YN-01-2023-005), Sichuan University "From 0 to 1" Innovative Research Project (2023SCUH0024).