Molecular mechanisms of aging and anti-aging strategies

作者全名：Li, Yumeng; Tian, Xutong; Luo, Juyue; Bao, Tongtong; Wang, Shujin; Wu, Xin

作者地址：[Li, Yumeng; Tian, Xutong; Luo, Juyue; Bao, Tongtong; Wu, Xin] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Ctr Technol Innovat Synthet Biol, Tianjin, Peoples R China; [Wang, Shujin] Chongqing Med Univ, Inst Life Sci, Chongqing, Peoples R China

通信作者：Wu, X (通讯作者)，Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Natl Ctr Technol Innovat Synthet Biol, Tianjin, Peoples R China.

来源：CELL COMMUNICATION AND SIGNALING

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001232493800001

JCR分区：Q1

影响因子：8.2

年份：2024

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Aging; Aging triggers; Synthetic; Senolytic; Anti-aging strategies

摘要：Aging is a complex and multifaceted process involving a variety of interrelated molecular mechanisms and cellular systems. Phenotypically, the biological aging process is accompanied by a gradual loss of cellular function and the systemic deterioration of multiple tissues, resulting in susceptibility to aging-related diseases. Emerging evidence suggests that aging is closely associated with telomere attrition, DNA damage, mitochondrial dysfunction, loss of nicotinamide adenine dinucleotide levels, impaired macro-autophagy, stem cell exhaustion, inflammation, loss of protein balance, deregulated nutrient sensing, altered intercellular communication, and dysbiosis. These age-related changes may be alleviated by intervention strategies, such as calorie restriction, improved sleep quality, enhanced physical activity, and targeted longevity genes. In this review, we summarise the key historical progress in the exploration of important causes of aging and anti-aging strategies in recent decades, which provides a basis for further understanding of the reversibility of aging phenotypes, the application prospect of synthetic biotechnology in anti-aging therapy is also prospected.

基金机构：Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project [TSBICIP-CXRC-031]

基金资助正文：This work was supported by Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project ( TSBICIP-CXRC-031).