Factors associated with SARS-CoV-2 vaccine hesitancy after stroke: a cross-sectional study

作者全名：Hu, Peng; Zhu, Ying-Hai; Bai, Chuan-Chuan; Wang, Wei; Li, Duo; Cao, Lei; Huang, Yan-Qing; Heng, Tian; Zhou, Xiao-Han; Liu, Tao; Luo, Ya-Xi; Yao, Xiu-Qing

作者地址：[Hu, Peng; Zhu, Ying-Hai; Bai, Chuan-Chuan; Heng, Tian; Zhou, Xiao-Han; Liu, Tao; Luo, Ya-Xi; Yao, Xiu-Qing] Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil, Chongqing, Peoples R China; [Yao, Xiu-Qing] Chongqing Municipal Clin Res Ctr Geriatr Med, Chongqing, Peoples R China; [Bai, Chuan-Chuan] Chongqing Med Univ, Univ Town Hosp, Dept Rehabil, Chongqing, Peoples R China; [Wang, Wei] Hubei Univ Med, Taihe Hosp, Affiliated Hosp, Cardiopulm Rehabil Ctr, Shiyan, Peoples R China; [Li, Duo] Univ South China, Nanhua Affiliated Hosp, Hengyang Med Sch, Dept Gen Med, Hengyang, Peoples R China; [Cao, Lei] First Hosp Yulin, Dept Emergency Med, Yulin, Peoples R China; [Huang, Yan-Qing] Guangzhou Rehabil Hosp Elderly, Dept Rehabil, Guangzhou, Peoples R China

通信作者：Luo, YX; Yao, XQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Rehabil, Chongqing, Peoples R China.; Yao, XQ (通讯作者)，Chongqing Municipal Clin Res Ctr Geriatr Med, Chongqing, Peoples R China.

来源：BMC PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001232516900001

JCR分区：Q1

影响因子：3.5

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：SARS-CoV-2; Vaccination status; Vaccine hesitancy; Stroke

摘要：Background The vaccination status of post-stroke patients, who are at high risk of severe outcomes from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), is a significant concern, yet it remains unclear. We aimed to explore the vaccination status, factors associated with vaccine hesitancy, and adverse effects after vaccination among post-stroke patients.Methods This multi-center observational study enrolled hospitalized post-stroke patients from six Chinese hospitals (Oct 1, 2020 - Mar 31, 2021), examining vaccine uptake and self-reported reasons for vaccine hesitancy, utilizing logistic regression to investigate risk factors for vaccine hesitancy, and recording any adverse reactions post-vaccination.Results Of the total 710 post-stroke patients included in the study, 430 (60.6%) had completed the recommended full-3 dose SARS-CoV-2 vaccination, with 176 (24.8%) remaining unvaccinated. The most common reasons for vaccine hesitancy were concerns about vaccine side effects (41.5%) and impaired mobility (33.9%). Logistic regression identified advanced age (aOR = 1.97, 95%CI: 1.36-2.85, P = 0.001), lower Barthel Index score (aOR = 0.88, 95%CI: 0.82-0.93, P = 0.018), higher Modified Rankin Scale score (aOR = 1.85, 95%CI: 1.32-2.56, P = 0.004), and poorer usual activity level of EuroQol 5-Dimension (aOR = 2.82, 95%CI: 1.51-5.28, P = 0.001) as independent risk factors for vaccine hesitancy. Approximately 14.8% reported minor adverse reactions, mainly pain at the injection site.Conclusion We found that post-stroke patients have insufficient SARS-CoV-2 vaccination rates, with key risk factors for vaccine hesitancy including concerns about side effects, advanced age, and functional impairments. No severe adverse reactions were observed among the vaccinated population.

基金机构：National Natural Science Foundation of China

基金资助正文：We would like to thank Dr. Su Shu from the Department of Epidemiology and Biostatistics at the Second Affiliated Hospital of Chongqing Medical University for her valuable statistical advice.