Relationships among anxiety, depression, and health-related quality of life in adult epilepsy: A network analysis

作者全名：Song, Hui; Zhao, Yuping; Hu, Chunmei; Zhao, Chenxiao; Wang, Xuefeng; Xiao, Zheng

作者地址：[Song, Hui; Zhao, Yuping; Hu, Chunmei; Zhao, Chenxiao; Wang, Xuefeng; Xiao, Zheng] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Hu, Chunmei] Peoples Hosp Nanchuan, Dept Neurol, Chongqing, Peoples R China

通信作者：Wang, XF; Xiao, Z (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.

来源：EPILEPSY & BEHAVIOR

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001232631400001

JCR分区：Q2

影响因子：2.3

年份：2024

卷号：154

期号：　

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结束页：　

文献类型：Article

关键词：Adult epilepsy; Anxiety; Depression; Health-related quality of life; Network analysis

摘要：Objective: Comorbid depression and anxiety in patients with epilepsy (PWE) are common and frequently undertreated, thus, causing poor health-related quality of life (HRQoL). However, little is known regarding the interconnections between anxious/depressive symptoms and the dimensions of HRQoL. Therefore, we conducted a network analysis to explore these relationships in detail among Chinese adult PWE. Methods: A cohort of adult PWE was consecutively recruited from the First Affiliated Hospital of Chongqing Medical University. HRQoL, depression, and anxiety were measured with Quality of Life in Epilepsy Inventory31, Neurological Disorders Depression Inventory for Epilepsy, and Generalized Anxiety Disorder 7-Item Scale, respectively. A regularized partial correlation network was constructed to investigate the interconnections between symptoms of anxiety/depression and the dimensions of HRQoL. We calculated expected influence (EI) and bridge expected influence (BEI) values to identify the most influential nodes. Results: A total of 396 PWE were enrolled in this study, 78.1% of whom had focal onset epilepsy. The prevalence of anxiety and depression was 30.3% and 28.8%, respectively. The symptoms "frustrated" and "uncontrollable worry" had the highest EI values, whereas "emotional well-being", "seizure worry", "difficulty finding pleasure", and "nervousness or anxiety" had the highest BEI values. Conclusion: This study provides new insights into the relationships among anxiety, depression, and HRQoL. Critical central symptoms and bridge symptoms identified in the network might help to quickly identify PWE comorbid anxiety and depression in busy outpatient settings, thereby enabling early intervention and enhancing quality of life.

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