Efficacy of Huangma Ding or autologous platelet-rich gel for the diabetic lower extremity arterial disease patients with foot ulcers

作者全名：Wang, Xue-Qin; Pu, Dan-Lan; Leng, Wei-Ling; Lei, Xiao-Tian; Juan, Jiang; La, Zou; Yao, Ding; Xi, Jia-Zhuang; Jian, Li; Miao, Teng; Wu, Qi-Nan

作者地址：[Wang, Xue-Qin; Miao, Teng] Peoples Hosp Yubei Dist Chongqing City, Endocrinol Dept, Chongqing 401120, Peoples R China; [Pu, Dan-Lan] Chongqing Yubei Dist Peoples Hosp, Dept Endocrinol, Chongqing 400030, Peoples R China; [Leng, Wei-Ling; Lei, Xiao-Tian] Army Med Univ, Affiliated Hosp 1, Endocrinol Dept, Chongqing 400038, Peoples R China; [Juan, Jiang; La, Zou; Yao, Ding] Chongqing Univ Canc Hosp, Endocrinol & Nephrol Dept, Chongqing 400016, Peoples R China; [Juan, Jiang; La, Zou; Yao, Ding] Chongqing Canc Inst, Chongqing 400016, Peoples R China; [Juan, Jiang; La, Zou; Yao, Ding] Chongqing Canc Hosp, Chongqing 400016, Peoples R China; [Xi, Jia-Zhuang; Jian, Li; Wu, Qi-Nan] Chongqing Med Univ, Dazu Hosp, Peoples Hosp Dazu, Dept Endocrinol, 1073 Second Ring South Rd,Tangxiang St, Chongqing 402360, Peoples R China

通信作者：Wu, QN (通讯作者)，Chongqing Med Univ, Dazu Hosp, Peoples Hosp Dazu, Dept Endocrinol, 1073 Second Ring South Rd,Tangxiang St, Chongqing 402360, Peoples R China.

来源：WORLD JOURNAL OF DIABETES

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001233271000003

JCR分区：Q1

影响因子：4.2

年份：2024

卷号：15

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：Diabetic foot ulcer; Huangma Ding; Autologous platelet-rich gel; Ankle-brachial index; Transcutaneous oxygen partial pressure

摘要：BACKGROUND Diabetes foot is one of the most serious complications of diabetes and an important cause of death and disability, traditional treatment has poor efficacy and there is an urgent need to develop a practical treatment method. AIM To investigate whether Huangma Ding or autologous platelet-rich gel (APG) treatment would benefit diabetic lower extremity arterial disease (LEAD) patients with foot ulcers. METHODS A total of 155 diabetic LEAD patients with foot ulcers were enrolled and divided into three groups: Group A (62 patients; basal treatment), Group B (38 patients; basal treatment and APG), and Group C (55 patients; basal treatment and Huangma Ding). All patients underwent routine follow-up visits for six months. After follow-up, we calculated the changes in all variables from baseline and determined the differences between groups and the relationships between parameters. RESULTS The infection status of the three groups before treatment was the same. Procalcitonin (PCT) improved after APG and Huangma Ding treatment more than after traditional treatment and was significantly greater in Group C than in Group B. Logistic regression analysis revealed that PCT was positively correlated with total amputation, primary amputation, and minor amputation rates. The ankle-brachial pressure and the transcutaneous oxygen pressure in Groups B and C were greater than those in Group A. The major amputation rate, minor amputation rate, and total amputation times in Groups B and C were lower than those in Group A. CONCLUSION Our research indicated that diabetic foot ulcers (DFUs) lead to major amputation, minor amputation, and total amputation through local infection and poor microcirculation and macrocirculation. Huangma Ding and APG were effective attreating DFUs. The clinical efficacy of Huangma Ding was better than that of autologous platelet gel, which may be related to the better control of local infection by Huangma Ding. This finding suggested that in patients with DFUs combined with coinfection, controlling infection is as important as improving circulation.

基金机构：Chongqing Science and Technology Bureau and Health Commission of Chinese Medicine Technology Innovation and Application Development Project [2020ZY013540]; General Project of Chongqing Natural Science Foundation [CSTB2023NSCQ-MSX0246, CSTB2022NSCQ-MSX1271]; Science and Health Joint Project of Dazu District Science and Technology Bureau [DZKJ2022JSYJ1001]

基金资助正文：Supported by the Chongqing Science and Technology Bureau and Health Commission of Chinese Medicine Technology Innovation and Application Development Project, No. 2020ZY013540; General Project of Chongqing Natural Science Foundation, No. CSTB2023NSCQ-MSX0246 and No. CSTB2022NSCQ-MSX1271; and Science and Health Joint Project of Dazu District Science and Technology Bureau, No. DZKJ2022JSYJ1001.