Higher LDL-C/HDL-C Ratio Is Associated with Elevated HbA1c and Decreased eGFR Levels and Cardiac Remodeling in Elderly with Hypercholesterolemia

作者全名：Li, Yufeng; Li, Gang; Laukkanen, Jari A.; Wei, Linping; Chen, Xinrui

作者地址：[Li, Yufeng; Li, Gang; Wei, Linping; Chen, Xinrui] Chongqing Med Univ, Affiliated Hosp 1, Dept Geriatr, Div Cardiol, Chongqing 400016, Peoples R China; [Laukkanen, Jari A.] Univ Eastern Finland, Inst Clin Med, Dept Med, Kuopio 70211, Finland; [Laukkanen, Jari A.] Univ Eastern Finland, Inst Publ Hlth & Clin Nutr, Kuopio 70211, Finland; [Laukkanen, Jari A.] Wellbeing Serv Cty Cent Finland, Dept Med, Jyvaskyla 40620, Finland

通信作者：Li, G (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Geriatr, Div Cardiol, Chongqing 400016, Peoples R China.

来源：JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE

ESI学科分类：　

WOS号：WOS:001233481400001

JCR分区：Q2

影响因子：2.4

年份：2024

卷号：11

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：hypercholesterolemia; glycated hemoglobin; glomerular filtration dysfunction; coronary heart disease; cardiac remodeling

摘要：Background: This study aims to explore the relationship of the low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein (HDL-C) ratio with glycated hemoglobin (HbA1c), renal dysfunction, coronary heart disease (CHD) and cardiac structure and function in elderly patients with hypercholesterolemia. Methods: A total of 1129 hospitalized Chinese elderly (aged >= 65 years) with hypercholesterolemia were collected retrospectively. The patients were divided into low (<2.63), moderate (>= 2.63 to <3.33) and high (>= 3.33) LDL-C/HDL-C ratio groups according to the tertiles of LDL-C/HDL-C. Results: Regression analysis of the LDL-C/HDL-C ratio with metabolic and echocardiographic parameters revealed that a high LDL-C/HDL-C ratio (>= 3.33) was associated independently with male gender, elevated HbA1c, decreased estimated glomerular filtration rate (eGFR), prevalent CHD and left ventricular dilatation (all p < 0.05). Conclusions: A high LDL-C/HDL-C ratio was associated with male gender, increased HbA1c, decreased eGFR, CHD and enlarged left ventricle in elderly with hypercholesterolemia.

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