Wernicke encephalopathy induced by glucose infusion: A case report and literature review

作者全名：Tao, Xiangkun; Qiao, Renjie; Liu, Can; Guo, Lu; Li, Jingcheng; Kang, Yulai; Wei, Youdong

作者地址：[Tao, Xiangkun] Chongqing Med Univ, Psychol Med Sci, Chongqing, Peoples R China; [Qiao, Renjie] Chongqing Med Univ, Clin Med Sci, Chongqing, Peoples R China; [Liu, Can] Army Med Univ, Daping Hosp, Dept Radiol, Chongqing 400042, Peoples R China; [Guo, Lu; Li, Jingcheng; Kang, Yulai] Army Med Univ, Daping Hosp, Dept Neurol, Chongqing 400042, Peoples R China; [Wei, Youdong] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Neurobiol, Chongqing, Peoples R China; [Kang, Yulai] 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China; [Wei, Youdong] 1 Youyi Rd, Chongqing, Yuanjiagang, Peoples R China

通信作者：Kang, YL (通讯作者)，10 Changjiang Branch Rd, Chongqing 400042, Peoples R China.; Wei, YD (通讯作者)，1 Youyi Rd, Chongqing, Yuanjiagang, Peoples R China.

来源：HELIYON

ESI学科分类：　

WOS号：WOS:001233559500003

JCR分区：Q1

影响因子：3.4

年份：2024

卷号：10

期号：8

开始页：　

结束页：　

文献类型：Review

关键词：Wernicke encephalopathy; Thiamine; Glucose; Case report

摘要：Introduction: Wernicke encephalopathy (WE) is a potentially fatal condition caused by thiamine (vitamin B1) deficiency. Chronic alcoholism is the most common cause of WE; however, other conditions responsible for thiamine deficiency should also be considered. Case Report: We report the case of a 64 -year -old woman with a history of diabetes who presented with confusion and apathy. Magnetic resonance imaging of the brain showed T2 hyperintensities involving dorsolateral medulla oblongata, tegmentum of the pons, vermis of the cerebellum, periaqueductal region, and the bilateral mammillary bodies. She had a history of intravenous glucose administration before her mental symptoms developed. On suspicion of WE, she was treated with a high dose of thiamine empirically. Her clinical condition improved rapidly in 2 weeks. Conclusion: Endogenous thiamine stores can be rapidly depleted in the case of enhanced glucose oxidation. Patients who receive glucose should also be prescribed thiamine to avoid inducing or exacerbating WE.

基金机构：National Natural Science Foundation of China [NSFC 81771287]; Chongqing Health and Family Planning Commission [2017MSXM023, 2017ZBXM046]

基金资助正文：This study was supported by National Natural Science Foundation of China (NSFC 81771287) and Chongqing Health and Family Planning Commission under grant numbers (2017MSXM023 and 2017ZBXM046) .