Corpus callosum and cerebellum participate in semantic dysfunction of Parkinson's disease: a diffusion tensor imaging-based cross-sectional study

作者全名：Liu, Hang; Zhong, Yuke; Liu, Guohui; Su, Huahua; Liu, Zhihui; Wei, Jiahao; Mo, Lijuan; Tan, Changhong; Liu, Xi; Chen, Lifen

作者地址：[Liu, Hang; Zhong, Yuke; Liu, Guohui; Su, Huahua; Liu, Zhihui; Wei, Jiahao; Mo, Lijuan; Tan, Changhong; Liu, Xi; Chen, Lifen] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, 74 Linjiang Rd, Chongqing 400010, Peoples R China

通信作者：Chen, LF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, 74 Linjiang Rd, Chongqing 400010, Peoples R China.

来源：NEUROREPORT

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001233735500003

JCR分区：Q4

影响因子：1.6

年份：2024

卷号：35

期号：6

开始页：366

结束页：373

文献类型：Article

关键词：cerebellum; corpus callosum; diffusion tensor imaging; Parkinson's disease; semantic fluency; white matter

摘要：Language dysfunction is common in Parkinson's disease (PD) patients, among which, the decline of semantic fluency is usually observed. This study aims to explore the relationship between white matter (WM) alterations and semantic fluency changes in PD patients. 127 PD patients from the Parkinson's Progression Markers Initiative cohort who received diffusion tensor imaging scanning, clinical assessment and semantic fluency test (SFT) were included. Tract-based special statistics, automated fiber quantification, graph-theoretical and network-based analyses were performed to analyze the correlation between WM structural changes, brain network features and semantic fluency in PD patients. Fractional anisotropy of corpus callosum, anterior thalamic radiation, inferior front-occipital fasciculus, and uncinate fasciculus, were positively correlated with SFT scores, while a negative correlation was identified between radial diffusion of the corpus callosum, inferior longitudinal fasciculus, and SFT scores. Automatic fiber quantification identified similar alterations with more details in these WM tracts. Brain network analysis positively correlated SFT scores with nodal efficiency of cerebellar lobule VIII, and nodal local efficiency of cerebellar lobule X. WM integrity and myelin integrity in the corpus callosum and several other language-related WM tracts may influence the semantic function in PD patients. Damage to the cerebellum lobule VIII and lobule X may also be involved in semantic dysfunction in PD patients.

基金机构：National Natural Science Foundation of China [82371262]; Natural Science Foundation of Chongqing [cstc2021jcyj-msxmX0180, CSTB2023NSCQ-MSX0104]; Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University; Graduate Students Science Innovation Project of Chongqing [CYS22349]

基金资助正文：This study is supported by National Natural Science Foundation of China (grant number: 82371262, receiver: L.C.), Natural Science Foundation of Chongqing (grant number: cstc2021jcyj-msxmX0180, receiver: X.L.; grant number: CSTB2023NSCQ-MSX0104, receiver: C.T.), Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University (receiver: X.L.) and Graduate Students Science Innovation Project of Chongqing (grant number: CYS22349, receiver: Y.Z.).