Gut microbiome alterations during gastric cancer: evidence assessment of case-control studies

作者全名：Zhang, Ruimin; Wu, Yingxin; Ju, Wantao; Wang, Senlin; Liu, Yanjun; Zhu, Hongmei

作者地址：[Zhang, Ruimin; Wu, Yingxin; Ju, Wantao; Wang, Senlin; Liu, Yanjun; Zhu, Hongmei] Southwest Jiaotong Univ, Inst Biomed Engn, Coll Med, Chengdu 610031, Peoples R China; [Zhang, Ruimin; Wu, Yingxin; Ju, Wantao; Wang, Senlin; Liu, Yanjun; Zhu, Hongmei] Southwest Jiaotong Univ, Chongqing Med Univ,Affiliated Hosp, Peoples Hosp Chengdu 3, Dept Gen Surg,Sect Gastrointestinal Surg, Chengdu, Peoples R China; [Zhang, Ruimin; Wu, Yingxin; Ju, Wantao; Wang, Senlin; Liu, Yanjun; Zhu, Hongmei] Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu, Peoples R China; [Ju, Wantao] Southwest Jiaotong Univ, Sch Life Sci & Engn, Chengdu, Peoples R China; [Zhu, Hongmei] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Med Res Ctr, Chengdu, Peoples R China

通信作者：Liu, YJ; Zhu, HM (通讯作者)，Southwest Jiaotong Univ, Inst Biomed Engn, Coll Med, Chengdu 610031, Peoples R China.; Liu, YJ; Zhu, HM (通讯作者)，Southwest Jiaotong Univ, Chongqing Med Univ,Affiliated Hosp, Peoples Hosp Chengdu 3, Dept Gen Surg,Sect Gastrointestinal Surg, Chengdu, Peoples R China.; Liu, YJ; Zhu, HM (通讯作者)，Chongqing Med Univ, Affiliated Hosp Chengdu 2, Chengdu, Peoples R China.; Zhu, HM (通讯作者)，Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Affiliated Hosp, Med Res Ctr, Chengdu, Peoples R China.

来源：FRONTIERS IN MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001233812100001

JCR分区：Q2

影响因子：4

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：gastric cancer; gastric microbiota; stomach; carcinogenesis; meta-analysis

摘要：Objectives The study aims to systematically identify the alterations in gut microbiota that observed in gastric cancer through comprehensive assessment of case-control studies. Methods: The systematic literature search of PubMed, Embase, Cochrane Library, and Web of Science was conducted to identify case-control studies that compared the microbiomes of individuals with and without gastric cancer. Quality of included studies was evaluated with the Newcastle-Ottawa Quality Assessment Scale (NOS). Meta-analyses utilized a random-effects model, and subgroup and sensitivity analyses were performed to assess study heterogeneity. All data analyses were performed using the "metan" package in Stata 17.0, and the results were described using log odds ratios (log ORs) with 95% confidence intervals (CIs). Results: A total of 33 studies involving 4,829 participants were eligible for analysis with 29 studies provided changes in alpha diversity and 18 studies reported beta diversity. Meta-analysis showed that only the Shannon index demonstrated statistical significance for alpha-diversity [-5.078 (-9.470, -0.686)]. No significant differences were observed at the phylum level, while 11 bacteria at genus-level were identified significant changed, e.g., increasing in Lactobacillus [5.474, (0.949, 9.999)] and Streptococcus [5.095, (0.293, 9.897)] and decreasing in Porphyromonas and Rothia with the same [-8.602, (-11.396, -5.808)]. Sensitivity analysis indicated that the changes of 9 bacterial genus were robust. Subgroup analyses on countries revealed an increasing abundance of Helicobacter and Streptococcus in Koreans with gastric cancer, whereas those with gastric cancer from Portugal had a reduced Neisseria. Regarding the sample sources, the study observed an increase in Lactobacillus and Bacteroides in the gastric mucosa of people with gastric cancer, alongside Helicobacter and Streptococcus. However, the relative abundance of Bacteroides decreased compared to the non-gastric cancer group, which was indicated in fecal samples. Conclusion: This study identified robust changes of 9 bacterial genus in people with gastric cancer, which were country-/sample source-specific. Large-scale studies are needed to explore the mechanisms underlying these changes.

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