The causal relationship between vitiligo and autoimmune thyroid diseases: A bidirectional two-sample Mendelian randomization analysis

作者全名：Chen, Yuhao; Zhang, Yunxuan; Liu, Wanshu; Huang, Xuhao; Luo, Xiaoyan; Wang, Hua

作者地址：[Chen, Yuhao; Zhang, Yunxuan; Liu, Wanshu; Huang, Xuhao; Luo, Xiaoyan; Wang, Hua] Chongqing Med Univ, Childrens Hosp, Key Lab Child Dev & Disorders, Natl Clin Res Ctr Child Hlth & Disorders,Minist Ed, Chongqing, Peoples R China; [Chen, Yuhao; Zhang, Yunxuan; Liu, Wanshu; Huang, Xuhao; Luo, Xiaoyan; Wang, Hua] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Child Rare Dis Infect & Immun, Chongqing, Peoples R China; [Luo, Xiaoyan; Wang, Hua] Chongqing Med Univ, Dept Dermatol, Childrens Hosp, Chongqing 400014, Peoples R China

通信作者：Luo, XY; Wang, H (通讯作者)，Chongqing Med Univ, Dept Dermatol, Childrens Hosp, Chongqing 400014, Peoples R China.

来源：SKIN RESEARCH AND TECHNOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001233934200001

JCR分区：Q3

影响因子：2

年份：2024

卷号：30

期号：6

开始页：　

结束页：　

文献类型：Article

关键词：autoimmune hyperthyroidism; autoimmune thyroiditis; genetics; Graves' disease; Mendelian randomization; vitiligo

摘要：Background: Vitiligo is an acquired autoimmune depigmented disorder characterized by the presence of white and well-defined patches on the skin, mucous membrane, or both. It is associated with a significant disease burden and has a profoundly impacts patients' quality of life. Autoimmune thyroid diseases (AITDs) result from an autoimmune system dysregulation, leading to an erroneous immune attack on the thyroid gland. Previous observational and epidemiological studies have suggested the association between vitiligo and AITDs. However, the bidirectional cause-effect relationship between vitiligo and AITDs has not been formally assessed. Method: Two-sample bidirectional Mendelian randomization (MR) analysis was conducted to explore potential causal relationships between genetically increased risk of vitiligo and AITDs, using summary statistics from genome-wide association studies in European populations. Causal effects were primarily estimated using the inverse variance weighted method, and additional quality control was performed using the MR-Egger, weighted median, simple mode, and weight mode methods. Sensitivity analysis was conducted to assess the robustness of the results. Results: The forward MR analysis showed a positive causal relationship between vitiligo and autoimmune thyroiditis (AIT), autoimmune hyperthyroidism (AIH), and Graves' disease (GD). The odds ratio (OR) were 1.17 (95% CI, 1.01-1.35; p = 0.04), 1.12 (95% CI, 1.03-1.22; p = 0.01), and 1.13 (95% CI, 1.06-1.20; p < 0.01), respectively. In the reverse MR analysis, a positive causal relationship was found between AIT and vitiligo, with an OR of 1.10 (95% CI, 1.01-1.35; p = 0.04). However, no causal relationship was observed between AIH (p = 0.10) or GD (p = 0.61) and vitiligo. Sensitivity analysis revealed no evidence of horizontal pleiotropy or heterogeneity. Conclusions: The genetic-level investigation provides evidence of a genetic causal association between susceptibility to vitiligo and an increased risk of AITDs. Additionally, the results demonstrate a genetic causal association between susceptibility to AIT and an increased risk of vitiligo, while not indicating a similar association with susceptibility to AIH or GD.

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