Immunogenicity evaluation of primary polio vaccination schedule with inactivated poliovirus vaccines and bivalent oral poliovirus vaccine

作者全名：Xu, Jiawei; Liu, Yang; Qiu, Wei; Li, Wenwen; Hu, Xiaoxiao; Li, Xia; Fan, Qiang; Tang, Wenge; Wang, Yujie; Wang, Qing; Yao, Ning

作者地址：[Xu, Jiawei; Liu, Yang; Qiu, Wei; Tang, Wenge; Wang, Qing; Yao, Ning] Chongqing Municipal Ctr Dis Control & Prevent, EPI Dept, 8 Changjiang 2nd St, Chongqing 400042, Peoples R China; [Li, Wenwen] Hechuan Dist Ctr Dis Control & Prevent, EPI Dept, Chongqing, Peoples R China; [Hu, Xiaoxiao] Liangping Dist Ctr Dis Control & Prevent, EPI Dept, Chongqing, Peoples R China; [Li, Xia] Rongchang Dist Ctr Dis Control & Prevent, EPI Dept, Chongqing, Peoples R China; [Fan, Qiang] Zhongxian Cty Ctr Dis Control & Prevent, EPI Dept, Chongqing, Peoples R China; [Wang, Yujie] Chongqing Med Univ, Sch Publ Hlth, Chongqing, Peoples R China; [Yao, Ning] Army Med Univ, Coll Prevent Med, Dept Hlth Stat, Chongqing 400038, Peoples R China

通信作者：Wang, Q; Yao, N (通讯作者)，Chongqing Municipal Ctr Dis Control & Prevent, EPI Dept, 8 Changjiang 2nd St, Chongqing 400042, Peoples R China.; Yao, N (通讯作者)，Army Med Univ, Coll Prevent Med, Dept Hlth Stat, Chongqing 400038, Peoples R China.

来源：BMC INFECTIOUS DISEASES

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001234481600003

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Immunogenicity; IPV; bOPV; Sequential immunization

摘要：Background To assess the immunogenicity of the current primary polio vaccination schedule in China and compare it with alternative schedules using Sabin or Salk-strain IPV (sIPV, wIPV). Methods A cross-sectional investigation was conducted at four sites in Chongqing, China, healthy infants aged 60-89 days were conveniently recruited and divided into four groups according to their received primary polio vaccination schedules (2sIPV + bOPV, 2wIPV + bOPV, 3sIPV, and 3wIPV). The sero-protection and neutralizing antibody titers against poliovirus serotypes (type 1, 2, and 3) were compared after the last dose. Results There were 408 infants completed the protocol. The observed seropositivity was more than 96% against poliovirus types 1, 2, and 3 in all groups. IPV-only groups induced higher antibody titers(GMT) against poliovirus type 2 (Median:192, QR: 96-384, P<0.05) than the "2IPV + bOPV" group. While the "2IPV + bOPV" group induced significantly higher antibody titers against poliovirus type 1 (Median:2048, QR: 768-2048, P<0.05)and type 3 (Median:2048, QR: 512-2048, P<0.05) than the IPV-only group. Conclusions Our findings have proved that the two doses of IPV with one dose of bOPV is currently the best polio routine immunization schedule in China.

基金机构：Chongqing Health Commission and Chongqing Science and Technology Commission

基金资助正文：Not applicable.