Predicting the potentially exacerbation of severe viral pneumonia in hospital by MuLBSTA score joint CD4+and CD8+T cell counts: construction and verification of risk warning model

作者全名：Chen, Xi; Ma, Bei; Yang, Yu; Zhang, Mu; Xu, Fang

作者地址：[Chen, Xi; Zhang, Mu; Xu, Fang] Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Chen, Xi; Ma, Bei; Yang, Yu] Peoples Hosp Chongqing, Dept Crit Care Med, Liangjiang New Area, Chongqing 401120, Peoples R China

通信作者：Zhang, M; Xu, F (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Crit Care Med, 1 Youyi Rd, Chongqing 400016, Peoples R China.

来源：BMC PULMONARY MEDICINE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001234784400001

JCR分区：Q2

影响因子：2.6

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Viral pneumonia; MuLBSTA score; Warning system

摘要：Purpose This study mainly focuses on the immune function and introduces CD4+, CD8+ T cells and their ratios based on the MuLBSTA score, a previous viral pneumonia mortality risk warning model, to construct an early warning model of severe viral pneumonia risk.Methods A retrospective single-center observational study was operated from January 2021 to December 2022 at the People's Hospital of Liangjiang New Area, Chongqing, China. A total of 138 patients who met the criteria for viral pneumonia in hospital were selected and their data, including demographic data, comorbidities, laboratory results, CT scans, immunologic and pathogenic tests, treatment regimens, and clinical outcomes, were collected and statistically analyzed.Results Forty-one patients (29.7%) developed severe or critical illness. A viral pneumonia severe risk warning model was successfully constructed, including eight parameters: age, bacterial coinfection, CD4+, CD4+/CD8+, multiple lung lobe infiltrations, smoking, hypertension, and hospital admission days. The risk score for severe illness in patients was set at 600 points. The model had good predictive performance (AUROC = 0.94397), better than the original MuLBSTA score (AUROC = 0.8241).Conclusion A warning system constructed based on immune function has a good warning effect on the risk of severe conversion in patients with viral pneumonia.

基金机构：Chongqing science and health joint medical research project

基金资助正文：Not applicable