The cross-sectional correlation between the oxidative balance score and cardiometabolic risk factors and its potential correlation with longitudinal mortality in patients with cardiometabolic risk factors

作者全名：Lai, Qiancheng; Ye, Liu; Luo, Jun; Zhang, Cheng; Wu, Qingchen; Shao, Yue

作者地址：[Lai, Qiancheng] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Cardiac Surg, Chengdu, Peoples R China; [Ye, Liu] Chongqing Med Univ, Affiliated Hosp 1, Hlth Management Ctr, Branch 1, Chongqing, Peoples R China; [Luo, Jun; Zhang, Cheng; Wu, Qingchen; Shao, Yue] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, 1 Youyi Rd, Chongqing, Peoples R China

通信作者：Shao, Y (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiothorac Surg, 1 Youyi Rd, Chongqing, Peoples R China.

来源：BMC PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:001236172000007

JCR分区：Q1

影响因子：3.5

年份：2024

卷号：24

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Cardiometabolic risk factors; Mortality; NHANES; Oxidative balance score

摘要：Background This study analyzes the correlation between oxidative balance score (OBS), cardiometabolic risk factors (CMRFs), and mortality in individuals with CMRFs.Methods Data were chosen from the National Health and Nutrition Examination Survey. The survey-weighted multivariable logistic regression models were implemented to explore the relationship between OBS and the risk of CMRFs. Then, Cox proportional hazard models were employed to estimate the impact of OBS on mortality in individuals with CMRFs.Results Following multivariate adjustment, the subjects in the highest quartile exhibited a 46% reduction in the risk of CMRFs, a 33% reduction in the risk of diabetes, a 31% reduction in the risk of hypertension, and a 36% reduction in the risk of hyperlipidemia, compared with those in the lowest quartile. Furthermore, each 1-unit increase in OBS was remarkably negatively correlated with the prevalence of CMRFs, diabetes, hypertension, and hyperlipidemia. The correlation between OBS and CMFRs was found to be mediated by serum gamma-glutamyltransferase (GGT) and white blood cells (WBC), and the mediation effect of GGT levels and WBC, accounting for 6.90% and 11.51%, respectively. Lastly, the multivariate Cox regression model revealed that elevated OBS, irrespective of whether it was treated as a categorical or continuous variable, exhibited a significant association with decreased mortality from all causes, cardiovascular disease, and cancer.Conclusions An increased OBS might reflect a lower risk of CMRFs and a favorable prognosis for individuals with CMRFs. Moreover, WBC and GGT may play a potential mediating role between OBS and CMRFs.

基金机构：Chengdu Science and Technology Bureau

基金资助正文：None.