For the occurrence of PPCPs from source to tap: A novel approach modified in terms of sample preservation and SPE cartridge to monitor PPCPs in our water supply
作者全名：Wang, Yu; Yang, Qianzhan; Zhang, Huadong; Wang, Zhenghong; Wu, Ailin; Luo, Yun; Zhou, Qianru
作者地址：[Wang, Yu; Zhang, Huadong; Wang, Zhenghong; Wu, Ailin; Zhou, Qianru] Chongqing Ctr Dis Control & Prevent, Chongqing, Peoples R China; [Zhou, Qianru] Chongqing Med Univ, Coll Publ Hlth, Chongqing, Peoples R China; [Yang, Qianzhan] Shimadzu China Corp, Chongqing Branch, Chongqing, Peoples R China; [Luo, Yun] Raykol Grp Corp Ltd, Xiamen, Fujian, Peoples R China
通信作者：Zhou, QR (通讯作者)，Chongqing Ctr Dis Control & Prevent, Chongqing, Peoples R China.
来源：ANALYTICA CHIMICA ACTA
ESI学科分类：CHEMISTRY
WOS号：WOS:001236429500001
JCR分区：Q1
影响因子：5.7
年份：2024
卷号：1308
期号：
开始页：
结束页：
文献类型：Article
关键词：Pharmaceutical and personal care products; Sample preservation; In-lab fabricated SPE cartridge; Liquid chromatography tandem with mass spectrometry; Drinking water
摘要：Background: The ongoing infusion of pharmaceutical and personal care products (PPCPs) into ecosystems sustains a perpetual life cycle and leads to multi-generational exposures. Limited understanding of their environmental impact and their intrinsic ability to induce physiological effect in humans, even at low doses, pose great risks to human health. Few scholarly works have conducted systematic research into the occurrence of PPCPs within potable water systems. Concurrently, the associated monitoring techniques have not been comprehensively examined with regards to the specific nature of drinking water, namely whether the significant presence of disinfectants may influence the detection of PPCPs. Results: A modified approach in terms of detailed investigation of sample preservation and optimization of an inlab fabricated solid phase extraction (SPE) cartridge filled with DVB-VP and PS-DVB sorbent was proposed. Favorable methodological parameters were achieved, with correlation coefficients spanning from 0.9866 to 0.9998. The LODs of the PPCPs fluctuated from 0.001 to 2 mu g L-1, while the LOQs varied from 0.002 to 5 mu g L-1. The analysis of spiked samples disclosed a methodological precision of 2.31-9.86 % and a recovery of 52.4-119 %. We utilized the established method for analyzing 14 water samples of three categories (source water, finished water and tap water) from five centralized water supply plants. A total of 24 categories encompassing 72 PPCPs were detected, with the concentrations of PPCPs manifested a marked decrease from source water to finished water and finally to tap water. Significance: Our research meticulously examined the enhancement and purification effects of widely used commercial SPE cartridges and suggested the use of in -lab fabricated SPE cartridges packed with DVB-VP and PSDVB adsorbents. We also conducted a systematic evaluation of the need to incorporate ascorbic acid and sodium thiosulfate as preservatives for PPCP measurement, in consideration of the unique characteristics of drinking water matrices, specifically, the significant concentration levels of disinfectants. Furthermore, the proposed method was effectively employed to study the presence of PPCPs in source water, finished water, and tap water collected from centralized water supply plants.
基金机构：Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2021MSXM093]
基金资助正文：This research was funded by the Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) with project number of 2021MSXM093. The authors declare that they have no known competing financial interests or personal relationship that could have appeared to influence the work expounded in this paper.
