A Preliminary Study on the Application of Contrast-Enhanced Ultrasonography in Children With Peripheral Neuroblastic Tumors

作者全名：Wang, Ting; Han, Dan; Xiao, Huan; Yang, Hao; Chen, Jing-Yu; Tang, Yi

作者地址：[Wang, Ting; Han, Dan; Xiao, Huan; Yang, Hao; Chen, Jing-Yu; Tang, Yi] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Key Lab Child Dev & Disorders, Chongqing Key Lab Child Rare Dis Infect & Immun,Mi, Chongqing, Peoples R China; [Tang, Yi] Chongqing Med Univ, Childrens Hosp, Chongqing 400014, Peoples R China

通信作者：Tang, Y (通讯作者)，Chongqing Med Univ, Childrens Hosp, Chongqing 400014, Peoples R China.

来源：ULTRASOUND IN MEDICINE AND BIOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001237269500001

JCR分区：Q2

影响因子：2.4

年份：2024

卷号：50

期号：6

开始页：954

结束页：960

文献类型：Article

关键词：Pediatric; Peripheral neuroblastic tumors; Ganglioneuroma; Ganglioneuroblastoma; Neuroblastoma; Contrast -enhanced ultrasound

摘要：The purpose of this study was to retrospectively analyze the characteristics of contrast-enhanced ultrasound (CEUS) images and quantitative parameters of time-intensity curves (TICs) in children's peripheral neuroblastic tumors (pNTs). By comparing the imaging features and quantitative parameters of the TICs of neuroblastoma (NB) and ganglioneuroblastoma (GNB) patients, we attempted to identify the distinguishing points between NB and GNB. A total of 35 patients confirmed to have pNTs by pathologic examination were included in this study. Each child underwent CEUS with complete imaging data (including still images and at least 3 min of video files). Twenty-four patients were confirmed to have NB, and 11 were considered to have GNB according to differentiation. The CEUS image features and quantitative parameters of the TICs of all lesions were analyzed to determine whether there were CEUS-related differences between the two types of pNT. There was a significant difference in the enhancement patterns of the CEUS features (chi(2) = 5.303, p < 0.05), with more "peripheral-central" enhancement in the NB group and more "central-peripheral" enhancement in the GNB group. In the TIC, the rise time and time to peak were significantly different (p < 0.05). The receiver operating characteristic curve showed that the probability of ganglion cell NB increased significantly after RT > 15.29, with a sensitivity of 0.636 and a specificity of 0.958. When the peak time was greater than 16.155, the probability of NB increased significantly, with a sensitivity of 0.636 and a specificity of 0.958. The CEUS features of NB and GNB patients are very similar, and it is difficult to distinguish them. Rise time and time to peak may be useful in identifying GNB and NB, but the sample size of this study was small, and the investigation was only preliminary; a larger sample size is needed to support these conclusions.

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