Comprehensive analysis of the oral microbiota and metabolome change in patients of burning mouth syndrome with psychiatric symptoms

作者全名：Luo, Shihong; Lou, Fangzhi; Yan, Li; Dong, Yunmei; Zhang, Yingying; Liu, Yang; Ji, Ping; Jin, Xin

作者地址：[Luo, Shihong; Lou, Fangzhi; Yan, Li; Dong, Yunmei; Zhang, Yingying; Liu, Yang; Ji, Ping; Jin, Xin] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Luo, Shihong] Southwest Med Univ, Affiliated Stomatol Hosp, Dept Oral Implantol, Luzhou, Peoples R China; [Jin, Xin] Chongqing Med Univ, Stomatol Hosp, 426 Songshi North Rd, Chongqing 401147, Peoples R China

通信作者：Jin, X (通讯作者)，Chongqing Med Univ, Stomatol Hosp, 426 Songshi North Rd, Chongqing 401147, Peoples R China.

来源：JOURNAL OF ORAL MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:001237755400001

JCR分区：Q2

影响因子：3.7

年份：2024

卷号：16

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Burning mouth syndrome; psychiatric symptoms; oral microbiota; 16S rRNA; metabolism

摘要：BackgroundBurning mouth syndrome (BMS) is a chronic idiopathic facial pain with intraoral burning or dysesthesia. BMS patients regularly suffer from anxiety/depression, and the association of psychiatric symptoms with BMS has received considerable attention in recent years. The aims of this study were to investigate the potential interplay between psychiatric symptoms and BMS.MethodsUsing 16S rRNA sequencing and liquid chromatography-mass spectrometry (LC/MS) to evaluate the oral microbiota and saliva metabolism of 40 BMS patients [including 29 BMS patients with depression or anxiety symptoms (DBMS)] and 40 age matched healthy control (HC).ResultsThe oral microbiota composition in BMS exhibited no significant differences from HC, although DBMS manifested decreased alpha-diversity relative to HC. Noteworthy was the discernible elevation in the abundance of proinflammatory microorganisms within the oral microbiome of individuals with DBMS. Parallel findings in LC/MS analyses revealed discernible disparities in metabolites between DBMS and HC groups. Principal differential metabolites were notably enriched in amino acid metabolism and lipid metabolism, exhibiting associations with infectious and immunological diseases. Furthermore, the integrated analysis underscores a definitive association between the oral microbiome and metabolism in DBMS.ConclusionsThis study suggests possible future modalities for better understanding the pathogenesis and personalized treatment plans of BMS.

基金机构：National Natural Science Foundations of China [82370968]; Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX1148]

基金资助正文：The study was supported by grants from the National Natural Science Foundations of China [No. 82370968] and the Natural Science Foundation of Chongqing [No. CSTB2022NSCQ-MSX1148].