Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects

作者全名：Xiao, Yuji; Xiao, Xuefei; Zhang, Xue; Yi, Dongxin; Li, Tao; Hao, Qiangqiang; Zhang, Feng; Li, Xu; Wang, Ningning

作者地址：[Xiao, Yuji; Zhang, Xue; Yi, Dongxin; Hao, Qiangqiang; Zhang, Feng] Dalian Med Univ, Sch Publ Hlth, Dalian, Liaoning, Peoples R China; [Xiao, Yuji; Xiao, Xuefei] Chongqing Med Univ, Bishan Hosp, Chongqing, Peoples R China; [Zhang, Xue] Second Peoples Hosp Dalian, Dalian, Liaoning, Peoples R China; [Li, Tao] Dalian Med Univ, Dept Cardiol, Affiliated Hosp 1, Dalian, Liaoning, Peoples R China; [Li, Xu] Dalian Med Univ, Dept Clin Nutr, Affiliated Hosp 2, Dalian, Liaoning, Peoples R China; [Wang, Ningning] Dalian Med Univ, Global Hlth Res Ctr, Sch Publ Hlth, Dept Nutr & Food Hyg, Dalian, Liaoning, Peoples R China; [Wang, Ningning] Dalian Med Univ, Global Hlth Res Ctr, Dalian, Liaoning, Peoples R China

通信作者：Li, X (通讯作者)，Dalian Med Univ, Dept Clin Nutr, Affiliated Hosp 2, Dalian, Liaoning, Peoples R China.; Wang, NN (通讯作者)，Dalian Med Univ, Global Hlth Res Ctr, Sch Publ Hlth, Dept Nutr & Food Hyg, Dalian, Liaoning, Peoples R China.; Wang, NN (通讯作者)，Dalian Med Univ, Global Hlth Res Ctr, Dalian, Liaoning, Peoples R China.

来源：EPMA JOURNAL

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001237872500001

JCR分区：Q1

影响因子：6

年份：2024

卷号：15

期号：2

开始页：207

结束页：220

文献类型：Review

关键词：Mediterranean diet; Well-being; Optimal dietary treatment; Individualized patient profile; MedDiet; Chronic disease prevention; Cardiovascular disease; Hypertension; Type 2 diabetes mellitus; Obesity; Metabolic syndrome; Osteoporosis; Cancer; Predictive preventive personalized medicine; Personalized dietary customization; Healthcare economy; PPPM / 3PM; Mitochondria; Anti-inflammatory and antioxidant effects; Improved individual outcomes; Primary and secondary care

摘要：The prevalence of chronic diseases is currently a major public health issue worldwide and is exploding with the population growth and aging. Dietary patterns are well known to play a important role in our overall health and well-being, and therefore, poor diet and malnutrition are among the most critical risk factors for chronic disease. Thus, dietary recommendation and nutritional supplementation have significant clinical implications for the targeted treatment of some of these diseases. Multiple dietary patterns have been proposed to prevent chronic disease incidence, like Dietary Approaches to Stop Hypertension (DASH) and Diabetes Risk Reduction Diet (DRRD). Among them, the MedDiet, which is one of the most well-known and studied dietary patterns in the world, has been related to a wide extent of health benefits. Substantial evidence has supported an important reverse association between higher compliance to MedDiet and the risk of chronic disease. Innovative strategies within the healthcare framework of predictive, preventive, and personalized medicine (PPPM/3PM) view personalized dietary customization as a predictive medical approach, cost-effective preventive measures, and the optimal dietary treatment tailored to the characteristics of patients with chronic diseases in primary and secondary care. Through a comprehensive collection and review of available evidence, this review summarizes health benefits of MedDiet in the context of PPPM/3PM for chronic diseases, including cardiovascular disease, hypertension, type 2 diabetes, obesity, metabolic syndrome, osteoporosis, and cancer, thereby a working hypothesis that MedDiet can personalize the prevention and treatment of chronic diseases was derived.

基金机构：National Natural Science Foundation of China

基金资助正文：No Statement Available