The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among US adults: analysis of NHANES data

作者全名：Wang, Jinzhou; Li, Shanshan; Pu, Hongyu; He, Jiangtao

作者地址：[Wang, Jinzhou; He, Jiangtao] North Sichuan Med Coll, Dept Orthopaed Surg, Affiliated Hosp, Nanchong 637000, Sichuan, Peoples R China; [Li, Shanshan] Chongqing Med Univ, Dept Hepatobiliary Surg, Affiliated Hosp 1, Chongqing 400000, Peoples R China; [Pu, Hongyu] Fushun Peoples Hosp, Dept Orthopaed Surg, Zigong 643000, Sichuan, Peoples R China

通信作者：He, JT (通讯作者)，North Sichuan Med Coll, Dept Orthopaed Surg, Affiliated Hosp, Nanchong 637000, Sichuan, Peoples R China.

来源：LIPIDS IN HEALTH AND DISEASE

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001238230000003

JCR分区：Q2

影响因子：3.9

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：NHHR; Bone mineral density; Osteoporosis; NHANES

摘要：Background Osteoporosis and atherosclerosis frequently afflict older adults, and recent insights suggest a deeper connection between these conditions that surpasses mere aging effects. The ratio of non-high-density to high-density lipoprotein cholesterol (NHHR) has emerged as a novel lipid marker for evaluating the risk of cardiovascular diseases. Nonetheless, investigations into the correlation of the NHHR with the risk of developing osteoporosis remain unexplored.Methods We collected NHHR and bone mineral density (BMD) data from 11,024 National Health and Nutrition Examination Survey (NHANES) participants between 2011 and 2018. Multivariate linear regression was employed to examine the correlation between BMD and NHHR. Smooth curves were employed to deal with the nonlinearity. To further account for the nonlinear link, we used a two-part linear regression model. The threshold effects were estimated using two components of a linear regression model. Subgroup and sensitivity analyses were carried out to ascertain the stability of the findings.Results We discovered a negative relationship between the NHHR and lumbar spine BMD in all three models. An L-shaped curvilinear association existed between the NHHR and lumbar spine BMD, with a key inflection point of 6.91. The fully adjusted model showed that the BMD of the lumbar spine fell by 0.03 g/cm2 in those who were in the fourth quartile as opposed to the lowest quartile. The sensitivity analysis using unweighted logistic analysis verified the stability of the results. In addition, BMD in the nondiabetic group was more significantly affected by the negative effect of the NHHR in the subgroup analysis.Conclusions According to this research, there appears to be a negative correlation between BMD and NHHR in US Adults. To clarify the precise physiological mechanisms by which the NHHR contributes to the onset of osteoporosis, more research is necessary.

基金机构：　

基金资助正文：