TRPV1 in Dry Eye Disease

作者全名：Gou, Qingqing; Song, Zhi; Gong, Yu; Li, Jiawen

作者地址：[Gou, Qingqing; Song, Zhi; Gong, Yu; Li, Jiawen] Chongqing Med Univ, Dept Ophthalmol, Univ Town Hosp, Chongqing 401331, Peoples R China

通信作者：Gong, Y; Li, JW (通讯作者)，Chongqing Med Univ, Dept Ophthalmol, Univ Town Hosp, Chongqing 401331, Peoples R China.

来源：FRONTIERS IN BIOSCIENCE-LANDMARK

ESI学科分类：　

WOS号：WOS:001238337400022

JCR分区：Q2

影响因子：3.3

年份：2024

卷号：29

期号：5

开始页：　

结束页：　

文献类型：Review

关键词：review; TRPV1; dry eye disease (DED)

摘要：Dry eye disease (DED) is a prevalent ophthalmic ailment with intricate pathogenesis and that occurs primarily due to various factors which affect the ocular surface. DED is characterized by the disruption of tear film homeostasis, inflammatory reaction, and neuroparesthesia. Transient receptor potential vanilloid 1 (TRPV1) is a versatile receptor that can be stimulated by heat, acid, capsaicin (CAP), hyperosmolarity, and numerous inflammatory agents. There is accumulating evidence that implicates TRPV1 in the initiation and progression of DED through its detection of hypertonic conditions and modulation of inflammatory pathways. In this article, we present a comprehensive review of the expression and function of the TRPV1 channel in tissues and cells associated with DED. In addition, we outline the potential mechanisms that implicate TRPV1 in the pathophysiology of DED. The aim of this review is to establish a theoretical basis for TRPV1 as a possible therapeutic target in DED, thereby encouraging further investigations into its role in DED.

基金机构：Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission [CSTB2022NSCQ-MSX0065, CSTB2023NSCQ-MSX0194]; Program for Youth Innovation in Future Medicine, Chongqing Medical University [W0158]; Research Start-up Fund of "High-level Talent Introduction Program" of University-Town Hospital of Chongqing

基金资助正文：This study was financially supported by Natural Science Foundation Project of Chongqing, Chongqing Science and Technology Commission (Grant No. CSTB2022NSCQ-MSX0065 and No. CSTB2023NSCQ-MSX0194), the Program for Youth Innovation in Future Medicine, Chongqing Medical University (Grant No. W0158), and the Research Start-up Fund of "High-level Talent Introduction Program" of University-Town Hospital of Chongqing.