Clinical characteristics of cystic encephalomalacia in children

作者全名：Fan, Lijuan; Feng, Lianying; Gan, Jing; Luo, Rong; Qu, Haibo; Chen, Xiaolu

作者地址：[Fan, Lijuan; Gan, Jing; Luo, Rong; Chen, Xiaolu] Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Sichuan, Peoples R China; [Fan, Lijuan; Gan, Jing; Luo, Rong; Qu, Haibo; Chen, Xiaolu] Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Sichuan, Peoples R China; [Fan, Lijuan; Gan, Jing; Luo, Rong; Qu, Haibo; Chen, Xiaolu] Sichuan Univ, Key Lab Dev & Maternal & Child Dis Sichuan Prov, Chengdu, Sichuan, Peoples R China; [Feng, Lianying] Chongqing Med Univ, Childrens Hosp, Dept Neurol, Chongqing, Peoples R China; [Qu, Haibo] Sichuan Univ, West China Univ Hosp 2, Dept Radiol, Chengdu, Sichuan, Peoples R China

通信作者：Chen, XL (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Dept Pediat, Chengdu, Sichuan, Peoples R China.; Qu, HB; Chen, XL (通讯作者)，Sichuan Univ, Key Lab Birth Defects & Related Dis Women & Childr, Chengdu, Sichuan, Peoples R China.; Qu, HB; Chen, XL (通讯作者)，Sichuan Univ, Key Lab Dev & Maternal & Child Dis Sichuan Prov, Chengdu, Sichuan, Peoples R China.; Qu, HB (通讯作者)，Sichuan Univ, West China Univ Hosp 2, Dept Radiol, Chengdu, Sichuan, Peoples R China.

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001238532600001

JCR分区：Q2

影响因子：2.1

年份：2024

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：cystic encephalomalacia; clinical manifestations; medical imaging; MRI; pediatrics

摘要：Purpose To investigate the primary causes and clinical characteristics of cystic encephalomalacia (CE) in children.Methods The clinical data of 50 children who were admitted to our hospital due to CE between January 2008 and December 2020 were retrospectively reviewed. Their primary causes, clinical manifestations and cranial magnetic resonance imaging features were analyzed.Results Among all patients, 5 had prematurity, 19 had hypoxic-ischemic encephalopathy (HIE), 13 had intracranial infection, 14 had traumatic brain injury and hemorrhage, 4 had cerebral infarction, 2 had congenital genetic diseases, and 1 had hypoglycemia. The average time from primary disease onset to CE diagnosis was 70.1 +/- 61.0 days. The clinical manifestations included speech or motor developmental delay (n = 33), epilepsy (n = 31), dystonia (n = 27), limb paralysis (n = 16), and visual or auditory impairment (n = 5). Patients with HIE as the primary cause of CE had a significantly higher occurrence of dystonia, while a significantly higher incidence of paralysis was observed in those with cerebral infarction as the primary cause.Conclusion CE in children is mainly caused by HIE, intracranial infection, and cerebral hemorrhage. The major clinical manifestations included speech or motor developmental delay, epilepsy, and dystonia. Magnetic resonance imaging is an important tool for the diagnosis of CE.

基金机构：National Natural Science Foundation of China

基金资助正文：No Statement Available