Excessive load promotes temporomandibular joint chondrocyte apoptosis via Piezo1/endoplasmic reticulum stress pathway
作者全名：Wang, Xiaohui; Tao, Junli; Zhou, Jianping; Shu, Yi; Xu, Jie
作者地址：[Wang, Xiaohui; Tao, Junli; Zhou, Jianping; Shu, Yi; Xu, Jie] Chongqing Med Univ, Coll Stomatol, 426 North Songshi Rd, Chongqing 401147, Peoples R China; [Wang, Xiaohui; Tao, Junli; Zhou, Jianping; Shu, Yi; Xu, Jie] Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Wang, Xiaohui; Tao, Junli; Zhou, Jianping; Shu, Yi; Xu, Jie] Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Xu, Jie] Chongqing Med Univ, State Key Lab Ultrasound Med & Engn, Chongqing, Peoples R China
通信作者：Shu, Y; Xu, J (通讯作者)，Chongqing Med Univ, Coll Stomatol, 426 North Songshi Rd, Chongqing 401147, Peoples R China.
来源：JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
WOS号：WOS:001239265700001
JCR分区：Q2
影响因子：4.3
年份：2024
卷号：28
期号：11
开始页：
结束页：
文献类型：Article
关键词：apoptosis; endoplasmic reticulum stress; mechanotransduction; Piezo1; temporomandibular joint
摘要：Excessive load on the temporomandibular joint (TMJ) is a significant factor in the development of TMJ osteoarthritis, contributing to cartilage degeneration. The specific mechanism through which excessive load induces TMJ osteoarthritis is not fully understood; however, mechanically-activated (MA) ion channels play a crucial role. Among these channels, Piezo1 has been identified as a mediator of chondrocyte catabolic responses and is markedly increased in osteoarthritis. Our observations indicate that, under excessive load conditions, endoplasmic reticulum stress in chondrocytes results in apoptosis of the TMJ chondrocytes. Importantly, using the Piezo1 inhibitor GsMTx4 demonstrates its potential to alleviate this condition. Furthermore, Piezo1 mediates endoplasmic reticulum stress in chondrocytes by inducing calcium ion influx. Our research substantiates the role of Piezo1 as a pivotal ion channel in mediating chondrocyte overload. It elucidates the link between excessive load, cell apoptosis, and calcium ion influx through Piezo1. The findings underscore Piezo1 as a key player in the pathogenesis of TMJ osteoarthritis, shedding light on potential therapeutic interventions for this condition.
基金机构：Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering; National Natural Science Foundation of China [81800999]; Chongqing Health Commission & Science and Technology Bureau Foundation [2023ZDXM019]; CQMU Program for Youth Innovation in Future Medicine [W0135]; [2022KFKT003]
基金资助正文：The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: National Natural Science Foundation of China (Grant No. 81800999), Chongqing Health Commission & Science and Technology Bureau Foundation(NO.2023ZDXM019), CQMU Program for Youth Innovation in Future Medicine [No. W0135], Foundation of State Key Laboratory of Ultrasound in Medicine and Engineering (Grant No.2022KFKT003).
