Scutellarin-loaded pH/H 2 O 2 dual-responsive polymer cyclodextrin mesoporous silicon framework nanocarriers for enhanced cancer therapy

作者全名：Yi, Shouhui; Liao, Rongqiang; Zhao, Wei; Liu, Zuojin

作者地址：[Yi, Shouhui; Zhao, Wei] Chongqing Med Univ, Affiliated Hosp 2, Dept Canc Ctr, Chongqing 400010, Peoples R China; [Yi, Shouhui; Liu, Zuojin] Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing 400010, Peoples R China; [Liao, Rongqiang] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Pharm Dept, Chongqing 400014, Peoples R China

通信作者：Yi, SH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Canc Ctr, Chongqing 400010, Peoples R China.; Yi, SH; Liu, ZJ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Hepatobiliary Surg, Chongqing 400010, Peoples R China.

来源：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001239329900001

JCR分区：Q1

影响因子：7.7

年份：2024

卷号：269

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Mesoporous silicon; Cyclodextrin,stimulation-responsive; Intelligent nanomedicine; Scutellarin

摘要：Stimulus-responsive nanomaterials, particularly with targeting capabilities, have garnered significant attention in the cancer therapy. However, the biological safety of these innovative materials in vivo remains unknown, posing a hurdle to their clinical application. Here, a pH/H 2 O 2 dual-responsive and targeting nano carrier system (NCS) was developed using core shell structure of Fe 3 O 4 mesoporous silicon (MSN@Fe 3 O 4 ) as main body, scutellarin (SCU) as antitumor drug and polymer cyclodextrin (PCD) as molecular switch (denoted as PCD@SCU@MSN@Fe 3 O 4 , abbreviated as NCS). The NCS, with an average particle size of 100 nm, displayed exceptional SCU loading capacity, a result of its uniform radial channel structure. The in vitro investigation under condition of pH and H 2 O 2 indicated that NCS performed excellent pH/H 2 O 2 -triggered SCU release behavior. The NCS displayed a higher cytotoxicity against tumor cells (Huh7 and HCT116) due to its pH/H 2 O 2 dual-triggered responsiveness, while the PCD@MSN@Fe 3 O 4 demonstrated lower cytotoxicity for both Huh7 and HCT116 cells. In vivo therapeutic evaluation of NCS indicates significant inhibition of tumor growth in mouse subcutaneous tumor models, with no apparent side-effects detected. The NCS not only enhances the bioavailability of SCU, but also utilizes magnetic targeting technology to deliver SCU accurately to tumor sites. These findings underscore the substantial clinical application potential of NCS.

基金机构：Natural Science Foundation of Chongqing, China [CSTB2023NSCQ-MSX0247, CSTB2023NSCQ-MSX0200]

基金资助正文：This work was supported by the Natural Science Foundation of Chongqing, China [No. CSTB2023NSCQ-MSX0247, No. CSTB2023NSCQ-MSX0200] , which are gratefully acknowledged.