A meta-analysis of the relationship between abnormal pretreatment EEG and epilepsy recurrence

作者全名：Yao, Juan; Liao, Chengrong; Wang, Yao; Xiao, Zheng

作者地址：[Yao, Juan; Liao, Chengrong; Wang, Yao] Peoples Hosp Chongqing Liang Jiang New Area, Dept Electrophysiol, Chongqing 401147, Peoples R China; [Xiao, Zheng] First Affiliated Hosp Chongqing Med Univ, Dept Neurol, Chongqing 400016, Peoples R China

通信作者：Xiao, Z (通讯作者)，First Affiliated Hosp Chongqing Med Univ, Dept Neurol, Chongqing 400016, Peoples R China.

来源：EPILEPSY RESEARCH

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001239501000001

JCR分区：Q3

影响因子：2

年份：2024

卷号：203

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Epilepsy; EEG; Recurrence; Withdrawal

摘要：Background: Researchers have studied the risk factors for epilepsy recurrence among patients who withdraw from antiseizure medication (ASM). These studies aimed to determine the optimal time for ASM withdrawal. EEG findings are one of the risk factors that has been studied. However, it remains unclear whether abnormal pretreatment EEG findings are a risk factor for recurrence after ASM withdrawal. We performed this meta-analysis to clarify this issue. Methods: We retrieved literature from the PubMed and Embase databases, and used the Newcastle-Ottawa Scale to evaluate the methodological quality of the included studies. RevMan 5.3 software was used to analyse the data. Results: In total,710 articles were retrieved from the databases. Ultimately, after screening, 11 articles involving 1686 patients with epilepsy were included. Compared with that for a normal EEG, the odds ratio (OR) for an abnormal EEG was 1.10 (P=0.50), with an I2 value of 32% (P=0.15). Subgroup analysis revealed that the children-to-adolescents subgroup had an OR of 1.21 (P=0.27), and the children-to-adults subgroup had an OR of 0.64 (P=0.14) for an abnormal EEG. A separate subgroup analysis revealed that the focal epilepsy subgroup had an OR of 1.30 (P=0.37), and the generalized epilepsy and focal epilepsy subgroup had an OR of 1.07 (P=0.67) for an abnormal EEG. Conclusions: The risk of epilepsy recurrence is not related to pretreatment EEG findings, regardless of age or epilepsy classification. The associations of preand posttreatment EEG alterations with epilepsy recurrence are controversial. Due to the limitations of our article, further research is needed.

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