Engineering of phytic acid-coated Prussian nanoparticles for combined Nitric oxide and Low-Temperature photothermal therapy of osteosarcoma
作者全名：Zhang, Ye; Mou, Hai; Huang, Qiu; Jian, Changchun; Li, Xianglong; Chen, Sinan; Chen, Yuxing; Tao, Bailong; Ou, Yunsheng
作者地址：[Zhang, Ye; Chen, Sinan; Tao, Bailong] Chongqing Med Univ, Lab Res Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Zhang, Ye; Mou, Hai; Huang, Qiu; Chen, Sinan; Chen, Yuxing; Ou, Yunsheng] Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Yuzhong, Chongqing 400016, Peoples R China; [Zhang, Ye; Mou, Hai; Huang, Qiu; Chen, Sinan; Chen, Yuxing; Ou, Yunsheng] Chongqing Med Univ, Orthoped Lab, Yuzhong, Chongqing 400016, Peoples R China; [Jian, Changchun] North Sichuan Med Coll, Affiliated Hosp, Dept Orthopaed, Nanchong 637000, Sichuan, Peoples R China; [Li, Xianglong] Jiangxi Sci & Technol Normal Univ, Inst Organ Chem, Jiangxi Key Lab Organ Chem, Nanchang 330013, Peoples R China
通信作者：Tao, BL (通讯作者)，Chongqing Med Univ, Lab Res Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China.; Ou, YS (通讯作者)，Chongqing Med Univ, Dept Orthoped, Affiliated Hosp 1, Yuzhong, Chongqing 400016, Peoples R China.; Ou, YS (通讯作者)，Chongqing Med Univ, Orthoped Lab, Yuzhong, Chongqing 400016, Peoples R China.
来源：CHEMICAL ENGINEERING JOURNAL
ESI学科分类：ENGINEERING
WOS号：WOS:001240281900001
JCR分区：Q1
影响因子：13.3
年份：2024
卷号：491
期号：
开始页：
结束页：
文献类型：Article
关键词：Photothermal effect; Nitric oxide; Osteosarcoma; Prussian blue; Phytic acid; Apoptosis
摘要：The overall survival rate for osteosarcoma (OS) has not shown any improvement over the past three decades, highlighting the persistent challenge in diagnosing and treating this disease. Nitric oxide (NO) plays a crucial role in some forms of tumor therapy. However, achieving precise and targeted release of NO remains an obstacle in anti-tumor treatment. Given this circumstance, the utilization of near infrared (NIR) laser-induced photothermal effect offers promising potential for controlled delivery of NO. In this study, we have successfully developed a therapeutic nanoparticle, PB@SNP-PA, by loading NO donor sodium nitroprusside (SNP) into Prussian blue (PB) and coating it with phytic acid (PA) for bone targeting, achieving controlled release of NO and enhancing the anti-tumor effect under NIR laser. Moreover, PB@SNP-PA significantly impairs the mitochondria of OS cells, alleviate heat tolerance induced by heat shock proteins, and mediate apoptosis as a potential anticancer mechanism. By utilizing the bisphosphonate-adsorption property of phytic acid, we have achieved bone targeting for PB@SNP-PA, which exhibits significant intra-tumoral enrichment and remarkable anti-tumor effects in vivo by inhibiting bone dissolution. These findings suggest that PB@SNP-PA functions as a unique platform for controlled NO release, proposing a novel approach for combined anti-tumor therapy involving photothermal and gas therapies.
基金机构：National Natural Science Foundation of China [82172682, 82373221, 82102537]; Chongqing Science & Technology Commission [CSTB2023NSCQ-MSX0472, CSTC2021JCYJ-MSXMX0170, CSTB2022BSXM-JCX0039]; First Affiliated Hospital of Chongqing Medical University [CYYY-BSYJSCXXM-202207]; First Affiliated Hospital of Chongqing Medical University Cultivating Fund [PYJJ2021-02]; Clinical Medical College of North Sichuan Medical College Affiliated Hospital Research and Development Plan Project [2023-2GC003]
基金资助正文：This work was supported by the National Natural Science Foundation of China (No. 82172682, 82373221, and 82102537) , Chongqing Science & Technology Commission (No. CSTB2023NSCQ-MSX0472, CSTC2021JCYJ-MSXMX0170, and CSTB2022BSXM-JCX0039) , the 2022 First-class Discipline Construction Project of the First Affiliated Hospital of Chongqing Medical University (No. CYYY-BSYJSCXXM-202207) , the First Affiliated Hospital of Chongqing Medical University Cultivating Fund (No. PYJJ2021-02) , and the Clinical Medical College of North Sichuan Medical College Affiliated Hospital Research and Development Plan Project: 2023-2GC003.
