Post-stroke cognitive impairment: exploring molecular mechanisms and omics biomarkers for early identification and intervention

作者全名：Lu, Qiuyi; Yu, Anqi; Pu, Juncai; Chen, Dawei; Zhong, Yujie; Bai, Dingqun; Yang, Lining

作者地址：[Lu, Qiuyi; Yu, Anqi; Chen, Dawei; Zhong, Yujie; Bai, Dingqun; Yang, Lining] Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil, Chonging, Peoples R China; [Pu, Juncai] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chonging, Peoples R China

通信作者：Bai, DQ; Yang, LN (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Rehabil, Chonging, Peoples R China.

来源：FRONTIERS IN MOLECULAR NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001240394400001

JCR分区：Q2

影响因子：3.5

年份：2024

卷号：17

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：post-stroke cognitive impairment; omics; biomarkers; metabolomics; proteomics

摘要：Post-stroke cognitive impairment (PSCI) is a major stroke consequence that has a severe impact on patients' quality of life and survival rate. For this reason, it is especially crucial to identify and intervene early in high-risk groups during the acute phase of stroke. Currently, there are no reliable and efficient techniques for the early diagnosis, appropriate evaluation, or prognostication of PSCI. Instead, plenty of biomarkers in stroke patients have progressively been linked to cognitive impairment in recent years. High-throughput omics techniques that generate large amounts of data and process it to a high quality have been used to screen and identify biomarkers of PSCI in order to investigate the molecular mechanisms of the disease. These techniques include metabolomics, which explores dynamic changes in the organism, gut microbiomics, which studies host-microbe interactions, genomics, which elucidates deeper disease mechanisms, transcriptomics and proteomics, which describe gene expression and regulation. We looked through electronic databases like PubMed, the Cochrane Library, Embase, Web of Science, and common databases for each omics to find biomarkers that might be connected to the pathophysiology of PSCI. As all, we found 34 studies: 14 in the field of metabolomics, 5 in the field of gut microbiomics, 5 in the field of genomics, 4 in the field of transcriptomics, and 7 in the field of proteomics. We discovered that neuroinflammation, oxidative stress, and atherosclerosis may be the primary causes of PSCI development, and that metabolomics may play a role in the molecular mechanisms of PSCI. In this study, we summarized the existing issues across omics technologies and discuss the latest discoveries of PSCI biomarkers in the context of omics, with the goal of investigating the molecular causes of post-stroke cognitive impairment. We also discuss the potential therapeutic utility of omics platforms for PSCI mechanisms, diagnosis, and intervention in order to promote the area's advancement towards precision PSCI treatment.

基金机构：Program for Youth Innovation in Future Medicine, Chongqing Medical University

基金资助正文：No Statement Available