NET-targeted nanoparticles for antithrombotic therapy in pregnancy

作者全名：Zhou, Yijie; Xu, Lin; Jin, Pingsong; Li, Na; Chen, Xuehai; Yang, Anyu; Qi, Hongbo

作者地址：[Zhou, Yijie; Xu, Lin; Li, Na; Chen, Xuehai] Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing 400016, Peoples R China; [Jin, Pingsong; Qi, Hongbo] Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing 401147, Peoples R China; [Zhou, Yijie; Xu, Lin; Jin, Pingsong; Li, Na; Chen, Xuehai; Qi, Hongbo] Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing 400016, Peoples R China; [Qi, Hongbo] Chongqing Med Univ, Chinese Minist Educ, Joint Int Res Lab Reprod & Dev, Chongqing 400016, Peoples R China; [Zhou, Yijie; Xu, Lin] Guiyang Maternal & Child Hlth Care Hosp, Dept Dept Reprod Med, Guiyang 550003, Peoples R China; [Zhou, Yijie; Xu, Lin; Li, Na; Yang, Anyu] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China

通信作者：Chen, XH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Obstet, Chongqing 400016, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Women & Childrens Hosp, Dept Obstet & Gynecol, Chongqing 401147, Peoples R China.; Chen, XH; Qi, HB (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Maternal & Fetal Med, Chongqing 400016, Peoples R China.; Qi, HB (通讯作者)，Chongqing Med Univ, Chinese Minist Educ, Joint Int Res Lab Reprod & Dev, Chongqing 400016, Peoples R China.; Yang, AY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing 400010, Peoples R China.

来源：ISCIENCE

ESI学科分类：　

WOS号：WOS:001240443900001

JCR分区：Q1

影响因子：4.6

年份：2024

卷号：27

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要：Pulmonary embolism caused by deep vein thrombosis (DVT) is a major contributor to maternal morbidity and mortality. There is still an unmet need for safe and effective treatment options for DVT during pregnancy. Recent research has shown that neutrophil extracellular trap (NET) formation plays a very vital role in thrombosis. We created nanoparticles surface -modified by neutrophil elastase (NE) -binding peptide that can target activated neutrophils specifically in vitro and in vivo . Prussian blue nanoparticles (PB NPs) designed in the core scavenges abnormally elevated reactive oxygen species (ROS) in the vascular microenvironment and acts as a photothermal agent to mediate photothermal therapy (PTT) to damage fibrin network structure. Based on the data we have included, this noninvasive therapeutic approach is considered safe for both mothers and the fetus. Furthermore, our findings indicate that this therapeutic approach has a significant alleviation effect on intrauterine growth restriction caused by maternal thrombosis.

基金机构：National Natural Science Foundation of China for Youth [82001583]; General Program of National Natural Science Foundation of China [82171662]; The "111 program" of Ministry of Education P.R.C.; State Administration of Foreign Experts Affairs P.R.C.

基金资助正文：This research was supported by National Natural Science Foundation of China for Youth (grant number 82001583) , General Program of National Natural Science Foundation of China (grant number 82171662) , "111 program" of Ministry of Education P.R.C., and State Administration of Foreign Experts Affairs P.R.C.