The Impact of High Intensity Focused Ultrasound (HIFU) on Tumor-Specific Immune Responses of Prostate Cancer
作者全名：Chen, Wei; He, Lina; Huang, Haoran; Zeng, Xiang; Fu, Guangqing; Liu, Yi; Liang, Yong
作者地址：[Chen, Wei; Zeng, Xiang; Fu, Guangqing; Liang, Yong] Zigong Fourth Peoples Hosp, Dept Urol, Zigong 643000, Sichuan, Peoples R China; [Chen, Wei; He, Lina; Zeng, Xiang; Fu, Guangqing; Liu, Yi; Liang, Yong] Zigong Acad Big Data & Artificial Intelligence Med, Inst Precis Med, Zigong 643000, Sichuan, Peoples R China; [He, Lina] Zigong Hosp Women & Children Hlth Care, Dept Reprod Med, Zigong 643000, Sichuan, Peoples R China; [Huang, Haoran] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, Chongqing 400042, Peoples R China; [Liu, Yi] Sichuan Univ Sci & Engn, Coll Chem Engn, Zigong 643000, Sichuan, Peoples R China
通信作者：Chen, W (通讯作者)，Zigong Fourth Peoples Hosp, Dept Urol, Zigong 643000, Sichuan, Peoples R China.; Chen, W (通讯作者)，Zigong Acad Big Data & Artificial Intelligence Med, Inst Precis Med, Zigong 643000, Sichuan, Peoples R China.
来源：ARCHIVOS ESPANOLES DE UROLOGIA
ESI学科分类：CLINICAL MEDICINE
WOS号：WOS:001241153500001
JCR分区：Q4
影响因子：0.6
年份：2024
卷号：77
期号：4
开始页：322
结束页：330
文献类型：Review
关键词：high intensity focused ultrasound; focused ultrasound surgery; prostate cancer; anti-tumor immune responses; immunomodulation
摘要：High intensity focused ultrasound (HIFU), also referred to as focused ultrasound surgery (FUS), has garnered recent attention as a non-invasive therapeutic strategy for prostate cancer. It utilizes focused acoustic energy to achieve localized thermal ablation, while also potentially exerting immunomodulatory effects. This review aims to elucidate the mechanisms underlying how HIFU influences tumor -specific immune responses in prostate cancer. These mechanisms include the release of tumor -associated antigens and damage -associated molecular patterns, the activation of innate immune cells, the facilitation of antigen presentation to adaptive immune cells, the enhancement of activation and proliferation of tumor -specific cytotoxic T lymphocytes, and the attenuation of the immunosuppressive tumor microenvironment by reducing the activity of regulatory T cells and myeloid -derived suppressor cells. Both preclinical investigations and emerging clinical data in prostate cancer models highlight HIFU's potential to modulate the immune system, as evidenced by increased infiltration of effector immune cells, elevated levels of pro -inflammatory cytokines, and improved responsiveness to immune checkpoint inhibitors. HIFU induces immunogenic cell death, leading to the release of tumor antigens and danger signals that activate dendritic cells and facilitate cross -presentation to cytotoxic T cells. Additionally, FUS ablation reduces immunosuppressive cells and increases infiltration of CD8+ T cells into the tumor, reshaping the tumor microenvironment. By priming the immune system while overcoming immunosuppression, combining FUS with other immunotherapies like checkpoint inhibitors and cancer vaccines holds promise for synergistic anti -tumor effects. Despite challenges in optimizing parameters and identifying suitable patients, FUS represents a novel frontier by modulating the tumor microenvironment and enhancing anti -tumor immunity through a non-invasive approach.
基金机构：Zigong Key Scientific and Technology Project [2021KFKT019, 2022ZCYGY06, 2021YLSF25, 2023-YGY-1-01, 2022ZCYGY01]; Natural Science Foundation of Sichuan [2022NSFSC1287]; Zigong Medical Science Research Team and Platform [ZG-KY-2023-038, ZG-KY-2023-057, ZG-PT-2023-017, ZG-PT-2023-019, ZG-PT-2023-020, ZG-PT-2023-028]; Zigong Heath Commission Science Project [21YB067, 22YB060]
基金资助正文：This study was funded by Zigong Key Scientific and Technology Project (2021KFKT019, 2022ZCYGY06, 2021YLSF25, 2023-YGY-1-01 and 2022ZCYGY01) , Natural Science Foundation of Sichuan (2022NSFSC1287) , Zigong Medical Science Research Team and Platform (ZG-KY-2023-038, ZG-KY-2023-057, ZG-PT-2023-017, ZG-PT-2023-019, ZG-PT-2023-020 and ZG-PT-2023-028) and Zigong Heath Commission Science Project (21YB067 and 22YB060) .
