Angiogenesis in nasopharyngeal carcinoma: insights, imaging, and therapeutic strategies

作者全名：Xia, Chenxi; Zhao, Jia; Huang, Yu; Miao, Hongbin; Zhao, Feipeng

作者地址：[Xia, Chenxi; Zhao, Jia; Zhao, Feipeng] Southwest Med Univ, Affiliated Hosp, Dept Otolaryngol Head & Neck Surg, Luzhou, Sichuan, Peoples R China; [Huang, Yu; Zhao, Feipeng] Chengdu Second Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Chengdu 610017, Sichuan, Peoples R China; [Miao, Hongbin] Bishan Hosp Chongqing Med Univ, Bishan Hosp Chongqing, Dept Otolaryngol Head & Neck Surg, Chongqing, Peoples R China

通信作者：Zhao, FP (通讯作者)，Southwest Med Univ, Affiliated Hosp, Dept Otolaryngol Head & Neck Surg, Luzhou, Sichuan, Peoples R China.; Zhao, FP (通讯作者)，Chengdu Second Peoples Hosp, Dept Otolaryngol Head & Neck Surg, Chengdu 610017, Sichuan, Peoples R China.

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001242404200001

JCR分区：Q2

影响因子：3.5

年份：2024

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：nasopharyngeal carcinoma; angiogenesis; Epstein-Barr virus; exosomes; anti-angiogenic therapy

摘要：Nasopharyngeal carcinoma (NPC) is a highly prevalent head and neck malignancy in southern China frequently diagnosed at advanced stages owing to subtle early symptoms and associated metastasis. Angiogenesis emerges as a pivotal factor in NPC progression, with numerous angiogenesis-related factors showing aberrant expression and contributing to increased neovascularization within NPC tumors. These abnormal vessels not only nourish tumor growth but also facilitate metastasis, culminating in unfavorable patient outcomes. Multiple studies have demonstrated the applicability of various imaging techniques for assessing angiogenesis in NPC tumors, thus serving as a foundation for personalized treatment strategies and prognostic assessments. Anti-angiogenic therapies have exhibited significant potential for inhibiting NPC angiogenesis and exerting anti-tumor effects. To enhance efficacy, anti-angiogenic drugs are frequently combined with other treatment modalities to synergistically enhance anti-tumor effects while mitigating the side effects associated with single-agent therapies, consequently improving patient prognosis. Identifying the potential mechanisms and key targets underlying NPC angiogenesis and exploring more effective detection and treatment approaches holds promise for shaping the future of NPC diagnosis, treatment, and prognosis, thereby offering new avenues and perspectives for research and clinical practice.

基金机构：National Natural Science Foundation of China [81602570]; Health Commission of Sichuan Province [17ZB0465]; Education Department of Sichuan Province [17PJ532]

基金资助正文：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by the National Natural Science Foundation of China under Grant (81602570); the Health Commission of Sichuan Province under Grant (17ZB0465); and the Education Department of Sichuan Province under Grant (17PJ532).