Recent advances in the use of extracellular vesicles from adipose-derived stem cells for regenerative medical therapeutics

作者全名：Yang, Song; Sun, Yiran; Yan, Chenchen

作者地址：[Yang, Song] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China; [Sun, Yiran; Yan, Chenchen] Chengdu Med Coll, Sch Pharm, Chengdu 610500, Peoples R China

通信作者：Yang, S (通讯作者)，Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China.; Sun, YR (通讯作者)，Chengdu Med Coll, Sch Pharm, Chengdu 610500, Peoples R China.

来源：JOURNAL OF NANOBIOTECHNOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001243350700001

JCR分区：Q1

影响因子：10.6

年份：2024

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Review

关键词：Adipose-derived stem cell; Extracellular vesicle; Regenerative medicine; Tissue regeneration; Therapeutic effect; Underlying mechanism

摘要：Adipose-derived stem cells (ADSCs) are a subset of mesenchymal stem cells (MSCs) isolated from adipose tissue. They possess remarkable properties, including multipotency, self-renewal, and easy clinical availability. ADSCs are also capable of promoting tissue regeneration through the secretion of various cytokines, factors, and extracellular vesicles (EVs). ADSC-derived EVs (ADSC-EVs) act as intercellular signaling mediators that encapsulate a range of biomolecules. These EVs have been found to mediate the therapeutic activities of donor cells by promoting the proliferation and migration of effector cells, facilitating angiogenesis, modulating immunity, and performing other specific functions in different tissues. Compared to the donor cells themselves, ADSC-EVs offer advantages such as fewer safety concerns and more convenient transportation and storage for clinical application. As a result, these EVs have received significant attention as cell-free therapeutic agents with potential future application in regenerative medicine. In this review, we focus on recent research progress regarding regenerative medical use of ADSC-EVs across various medical conditions, including wound healing, chronic limb ischemia, angiogenesis, myocardial infarction, diabetic nephropathy, fat graft survival, bone regeneration, cartilage regeneration, tendinopathy and tendon healing, peripheral nerve regeneration, and acute lung injury, among others. We also discuss the underlying mechanisms responsible for inducing these therapeutic effects. We believe that deciphering the biological properties, therapeutic effects, and underlying mechanisms associated with ADSC-EVs will provide a foundation for developing a novel therapeutic approach in regenerative medicine.

基金机构：General Project of Natural Sciences Foundation of Chongqing

基金资助正文：The graphical abstract and Fig. 2, 3 were created with MedPeer (medpeer.cn). We would like to express our gratitude to both Chongqing Medical University and Chengdu Medical College for providing all the facilities required for the completion of this review.