Rheumatoid arthritis increases the risk of heart failure: results from the cross-sectional study in the US population and mendelian randomization analysis in the European population

作者全名：Kadier, Kaisaierjiang; Dilixiati, Diliyaer; Zhang, Xu; Li, Huan; Kuang, Lirong; Huang, Jian; Cai, Xintian; Ling, Tao; Kong, Fanqi; Liu, Xiaozhu

作者地址：[Kadier, Kaisaierjiang] Xinjiang Med Univ, Dept Cardiol, Affiliated Hosp 1, Urumqi, Peoples R China; [Dilixiati, Diliyaer] Xinjiang Med Univ, Dept Urol, Affiliated Hosp 1, Urumqi, Peoples R China; [Zhang, Xu] Chongqing Med Univ, Ctr Reprod Med, Chongqing Hlth Ctr Women & Children, Women & Childrens Hosp, Chongqing, Peoples R China; [Zhang, Xu] Chongqing Reprod & Genet Inst, Chongqing, Peoples R China; [Li, Huan] Chongqing Coll Elect Engn, Chongqing, Peoples R China; [Kuang, Lirong] Wuhan Univ Sci & Technol, Wuhan Wuchang Hosp, Dept Ophthalmol, Wuchang Hosp, Wuhan, Peoples R China; [Huang, Jian] Guangxi Univ Chinese Med, Grad Sch, Nanning, Peoples R China; [Huang, Jian] Zhejiang Univ, Coll Med, Sir Run Run Shaw Hosp, Dept Diagnost Ultrasound, Hangzhou, Peoples R China; [Cai, Xintian] Xinjiang Med Univ, Dept Grad Sch, Urumqi, Peoples R China; [Ling, Tao] Suqian First Hosp, Dept Pharm, Suqian, Peoples R China; [Kong, Fanqi] Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 3, Wenzhou, Peoples R China; [Liu, Xiaozhu] Capital Med Univ, Beijing Shijitan Hosp, Dept Crit Care Med, Beijing, Peoples R China

通信作者：Ling, T (通讯作者)，Suqian First Hosp, Dept Pharm, Suqian, Peoples R China.; Kong, FQ (通讯作者)，Wenzhou Med Univ, Dept Cardiol, Affiliated Hosp 3, Wenzhou, Peoples R China.; Liu, XZ (通讯作者)，Capital Med Univ, Beijing Shijitan Hosp, Dept Crit Care Med, Beijing, Peoples R China.

来源：FRONTIERS IN IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001243464600001

JCR分区：Q1

影响因子：5.7

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：rheumatoid arthritis; seronegative rheumatoid arthritis; heart failure; national health and nutrition examination survey; mendelian randomization

摘要：Objective: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Among its various complications, heart failure (HF) has been recognized as the second leading cause of cardiovascular death in RA patients. The objective of this study was to investigate the relationship between RA and HF using epidemiological and genetic approaches Methods: The study included 37,736 participants from the 1999-2020 National Health and Nutrition Examination Survey. Associations between RA and HF in the US population were assessed with weighted multivariate logistic regression analysis. A two-sample Mendelian randomization (MR) analysis was employed to establish the causal relationship between the two variables. The primary analysis method utilized was inverse variance weighting (IVW). Additionally, horizontal pleiotropy and heterogeneity were assessed to account for potential confounding factors. In cases where multiple independent datasets were accessible during MR analysis, we combined the findings through a meta-analytical approach. Results: In observational studies, the prevalence of HF in combination with RA reached 7.11% (95%CI 5.83 to 8.39). RA was positively associated with an increased prevalence of HF in the US population [odds ratio (OR):1.93, 95% confidence interval (CI):1.47-2.54, P < 0.0001]. In a MR analysis utilizing a meta-analytical approach to amalgamate the results of the IVW method, we identified a significant causal link between genetically predicted RA and a heightened risk of HF (OR = 1.083, 95% CI: 1.028-1.141; P = 0.003). However, this association was not deemed significant for seronegative RA (SRA) (OR = 1.028, 95% CI: 0.992-1.065; P = 0.126). These findings were consistent across sensitivity analyses and did not indicate any horizontal pleiotropy. Conclusion: RA correlates with an elevated prevalence of HF within the US population. Furthermore, genetic evidence derived from European populations underscores a causal link between RA and the risk of HF. However this association was not significant in SRA.

基金机构：Suqian SciTech Program [KY202312]

基金资助正文：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This research was supported by Suqian Sci&Tech Program (Grant No: KY202312).