The roles of B cells in cardiovascular diseases

作者全名：Ma, Jian; Wang, Xiaotong; Jia, Yuewang; Tan, Fangyan; Yuan, Xin; Du, Jianlin

作者地址：[Ma, Jian; Jia, Yuewang; Du, Jianlin] Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China; [Tan, Fangyan; Yuan, Xin] Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 2, 74 Lin Jiang Rd, Chongqing 4000L0, Peoples R China; [Wang, Xiaotong] Chongqing Med Univ, Dept Pediat, Childrens Hosp, Chongqing, Peoples R China

通信作者：Du, JL (通讯作者)，Chongqing Med Univ, Dept Cardiol, Affiliated Hosp 2, Chongqing, Peoples R China.; Yuan, X (通讯作者)，Chongqing Med Univ, Dept Nephrol, Affiliated Hosp 2, 74 Lin Jiang Rd, Chongqing 4000L0, Peoples R China.

来源：MOLECULAR IMMUNOLOGY

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001243680200001

JCR分区：Q2

影响因子：3.2

年份：2024

卷号：171

期号：　

开始页：36

结束页：46

文献类型：Article

关键词：B cells; Cardiac remodeling; Fibrosis; Heart diseases; Therapy

摘要：Damage to the heart can start the repair process and cause cardiac remodeling. B cells play an important role in this process. B cells are recruited to the injured place and activate cardiac remodeling through secreting antibodies and cytokines. Different types of B cells showed specific functions in the heart. Among all types of B cells, heart-associated B cells play a vital role in the heart by secreting TGF beta 1. B cells participate in the activation of fibroblasts and promote cardiac fibrosis. Four subtypes of B cells in the heart revealed the relationship between the B cells' heterogeneity and cardiac remodeling. Many cardiovascular diseases like atherosclerosis, heart failure (HF), hypertension, myocardial infarction (MI), and dilated cardiomyopathy (DCM) are related to B cells. The primary mechanisms of these B cell-related activities will be discussed in this review, which may also suggest potential novel therapeutic targets.

基金机构：National Natural Science Foundation of China (NSFC) [82270281]; Key Project of Technology Innovation and Application Development in Chongqing [CSTB2023TIAD-KPX0048]; Senior Medical Talents Program of Chongqing for Young and Middle-aged (JianlinDu [2022] ); Future Medicine Youth Innovation Team Development Support Program of Chongqing Medical University [W0133]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University

基金资助正文：<STRONG> </STRONG>This work was supported by grants from the National Natural Science Foundation of China (NSFC) (82270281) , Key Project of Technology Innovation and Application Development in Chongqing (CSTB2023TIAD-KPX0048) , Senior Medical Talents Program of Chongqing for Young and Middle-aged (JianlinDu [2022] ) , Future Medicine Youth Innovation Team Development Support Program of Chongqing Medical University (W0133) , Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University.