Exploring the prognostic significance of immunogenic cell death-related genes as risk biomarkers in cervical cancer

作者全名：Jin, Shuangmei; Chen, Jingdong

作者地址：[Jin, Shuangmei; Chen, Jingdong] Chongqing Med Univ, Bishan Hosp Chongqing, Bishan Hosp, Dept Gynaecol & Obstet, 9 Shuangxing Ave, Bishan 402760, Chongqing, Peoples R China

通信作者：Chen, JD (通讯作者)，Chongqing Med Univ, Bishan Hosp Chongqing, Bishan Hosp, Dept Gynaecol & Obstet, 9 Shuangxing Ave, Bishan 402760, Chongqing, Peoples R China.

来源：IMMUNITY INFLAMMATION AND DISEASE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:001244153000001

JCR分区：Q3

影响因子：3.1

年份：2024

卷号：12

期号：6

开始页：　

结束页：　

文献类型：Article

关键词：cervical cancer; immunogenic cell death; immunotherapy; prognosis; tumor immune infiltration

摘要：Background: Immunogenic cell death (ICD) is a process in which dying cells stimulate an immune response. It is a regulated form of cell death that can remodel the tumor microenvironment (TME) and activate the immune system, making immunotherapy more effective. This work was designed to identify prognostic gene features associated with ICD in cervical cancer (CC). Methods: Based on CC datasets and a set of ICD-related genes obtained from public databases, we first filtered out ICD-related genes unrelated to CC survival using univariate analysis. Subsequently, LASSO regression and multivariate Cox regression analysis were employed to develop prognostic feature genes based on ICD. For the construction and validation of the model, eight genes (CXCL1, IL1B, TNF, YKT6, PDIA3, ROCK1, CXCR3, and CLEC9A) were chosen. A nomogram was created to forecast the prognosis of CC individuals, and Kaplan-Meier curves were utilized to explore the survival disparities among different risk groups of CC individuals. Results: ssGSEA analysis was employed to investigate immune differences between two risk groups, revealing that the low-risk group exhibited elevated levels of immune cell infiltration, enhanced activation of immune function, and a higher immunophenoscore compared with the other group, which highlighted the relevance of ICD to TME. Conclusion: We constructed a prognostic model based on genetic biomarkers of ICD for prognostic prediction of CC patients. Our model demonstrated excellent discriminative and calibration capabilities, providing a valuable tool for prognostic prediction and assessing the potential efficacy of immunotherapy in CC.

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