Efficacy of transcutaneous electrical nerve stimulation combined with mirabegron therapy compared with mirabegron monotherapy for overactive bladder: a prospective randomized controlled study

作者全名：Zhao, Liang; Wu, Fanghao; Wang, Jinjin; Wang, Yuxin; Peng, Wei; Chen, Yuqin

作者地址：[Zhao, Liang] Peoples Hosp Yubei Dist Chongqing, Dept Urol, Chongqing, Peoples R China; [Wu, Fanghao; Wang, Jinjin; Wang, Yuxin; Peng, Wei] Gen Hosp Chongqing Steel Co, Dept Urol, Chongqing, Peoples R China; [Chen, Yuqin] Chongqing Med Univ, Coll Basic Med, Ctr Neurosci, Chongqing, Peoples R China

通信作者：Chen, YQ (通讯作者)，Chongqing Med Univ, Coll Basic Med, Ctr Neurosci, Chongqing, Peoples R China.

来源：WORLD JOURNAL OF UROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001244509900001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：42

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Overactive bladder; Transcutaneous electrical nerve stimulation; Mirabegron

摘要：PurposeThe objective was to evaluate the efficacy of transcutaneous electrical nerve stimulation (TENS) combined with mirabegron therapy compared with mirabegron monotherapy in the treatment of female patients with overactive bladder (OAB).MethodsIn this randomized controlled study, 100 female outpatients with OAB were screened. Among these patients, 86 who met the inclusion criteria were randomly divided into the TENS combined with mirabegron treatment group and mirabegron monotherapy treatment group, with 43 patients in each group. The voiding diary, Overactive Bladder Symptom Score (OABSS), Overactive Bladder Questionnaire Symptom Bother Score (OAB-q SBS), total health-related quality of life (OAB-q HRQoL), and treatment satisfaction-visual analog scale (TS-VAS) score before and after treatment were recorded to evaluate the efficacy of OAB treatment. Seventy-nine of the 86 patients (40 in the TENS plus mirabegron group and 39 in the mirabegron monotherapy group) completed 12 weeks of treatment.ResultsTENS combined with mirabegron therapy was superior to mirabegron monotherapy in improving the primary endpoints, including the daily number of micturition episodes and the daily MVV/micturition and secondary endpoints, including the daily number of urgency episodes, the OABSS, the OAB-q SBS, the HRQoL score and TS-VAS score. There were no statistically significant differences in urgency urinary incontinence and nocturia between the groups. Some minor adverse effects were observed, including muscle pain, local paresthesia and constipation.ConclusionsThe combination of TENS and mirabegron was more effective than mirabegron alone in the treatment of female patients with OAB.Trial registration numberChiCTR2400080528 (31.01.2024, retrospectively registered).

基金机构：Medical Scientific research project of Chongqing Municipal Health Commission to Liang Zhao [2023WSJK014]; Excellent Youth Program of the Basic Medical college of Chongqing Medical University

基金资助正文：This work was sponsored by the Medical Scientific research project of Chongqing Municipal Health Commission to Liang Zhao (No. 2023WSJK014), Excellent Youth Program of the Basic Medical college of Chongqing Medical University to Yuqin Chen.