Feasibility study of focused ultrasound in the treatment of vulvar low-grade squamous intraepithelial lesions with persistent symptoms

作者全名：Su, Chang; Liu, Xinglin; Wu, Can; Wang, Xi; Li, Chengzhi

作者地址：[Su, Chang; Liu, Xinglin; Wang, Xi; Li, Chengzhi] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China; [Su, Chang; Liu, Xinglin; Wang, Xi; Li, Chengzhi] Chongqing Med Univ, Chongqing Key Lab Biomed Engn, Chongqing, Peoples R China; [Wu, Can] Chongqing Haifu Hosp, Dept Gynecol, Chongqing, Peoples R China

通信作者：Li, CZ (通讯作者)，Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China.

来源：INTERNATIONAL JOURNAL OF HYPERTHERMIA

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001244521400001

JCR分区：Q2

影响因子：3

年份：2024

卷号：41

期号：1

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结束页：　

文献类型：Article

关键词：Focused ultrasound; vulvar low-grade squamous intraepithelial lesions; feasibility; efficacy; safety

摘要：Objective: This study aimed to investigate the feasibility, efficacy, and safety of focused ultrasound (FUS) for the treatment of vulvar low-grade squamous intraepithelial lesions (VLSIL) with persistent symptoms. Methods: This retrospective analysis included 24 VLSIL patients who underwent FUS treatment. At each follow-up visit, the clinical response was assessed including changes in symptoms and signs. In addition, the histological response was assessed based on the vulvar biopsy results of the 3rd follow-up. Clinical and histological response were assessed to elucidate the efficacy. Results: A total of 22 patients completed follow-up and post-treatment pathological biopsies. After treatment, the clinical scores of itching decreased from 2.55 +/- 0.51 to 0.77 +/- 0.81 (p < 0.05). Furthermore, the clinical response rate and histological response rate were 86.4% and 81.8%, respectively. Only two cured patients indicated recurrence in the 3rd and 4th year during the follow-up period and achieved cure after re-treatment. In terms of adverse effects, only one patient developed ulcers after treatment, which healed after symptomatic anti-inflammatory treatment without scarring, and no other treatment complications were found in any patients. None of the patients developed a malignant transformation during the follow-up period. Conclusion: This study revealed that FUS is feasible, effective, and safe for treating VLSIL patients with persistent symptoms, providing a new solution for the noninvasive treatment of symptomatic VLSIL.

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