Recent advances in injectable hydrogel therapies for periodontitis
作者全名：Ran, Shidian; Xue, Linyu; Wei, Xiaorui; Huang, Jindie; Yan, Xingrui; He, Tong-Chuan; Tang, Zhurong; Zhang, Hongmei; Gu, Mengqin
作者地址：[Ran, Shidian; Xue, Linyu; Wei, Xiaorui; Huang, Jindie; Yan, Xingrui; Zhang, Hongmei; Gu, Mengqin] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401147, Peoples R China; [He, Tong-Chuan] Univ Chicago, Med Ctr, Dept Orthopaed Surg & Rehabil Med, Mol Oncol Lab, Chicago, IL 60637 USA; [He, Tong-Chuan] Chongqing Med Univ, Key Lab Diagnost Med, Minist Educ, Chongqing 400016, Peoples R China; [He, Tong-Chuan] Chongqing Med Univ, Affiliated Hosp, Chongqing 400016, Peoples R China; [Tang, Zhurong] Chongqing Med Univ, Inst Life Sci, Chongqing 400016, Peoples R China
通信作者：Zhang, HM; Gu, MQ (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn High, Chongqing 401147, Peoples R China.
来源：JOURNAL OF MATERIALS CHEMISTRY B
ESI学科分类：MATERIALS SCIENCE
WOS号：WOS:001245187500001
JCR分区：Q1
影响因子：6.1
年份：2024
卷号：12
期号：25
开始页：6005
结束页：6032
文献类型：Review
关键词：
摘要：Periodontitis is an immune-inflammatory disease caused by dental plaque, and deteriorates the periodontal ligament, causes alveolar bone loss, and may lead to tooth loss. To treat periodontitis, antibacterial and anti-inflammation approaches are required to reduce bone loss. Thus, appropriate drug administration methods are significant. Due to their "syringeability", biocompatibility, and convenience, injectable hydrogels and associated methods have been extensively studied and used for periodontitis therapy. Such hydrogels are made from natural and synthetic polymer materials using physical and/or chemical cross-linking approaches. Interestingly, some injectable hydrogels are stimuli-responsive hydrogels, which respond to the local microenvironment and form hydrogels that release drugs. Therefore, as injectable hydrogels are different and highly varied, we systematically reviewed the periodontal treatment field from three perspectives: raw material sources, cross-linking methods, and stimuli-responsive methods. We then discussed current challenges and opportunities for the translation of hydrogels to clinic, which may guide further injectable hydrogel designs for periodontitis. Schematic illustration of injectable hydrogels in periodontitis treatment.
基金机构：Chongqing Postdoctoral Science Foundation [CSTB2023NSCQ-BHX0111]; Chongqing Postdoctoral Science Foundation [2024ZYYB005]; Chongqing Traditional Chinese Medicine scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [cstc2021jcyj-msxmX0061]; Natural Science Foundation of Chongqing [CYS23348]; Chongqing Scientific Research and Innovation Project for Postgraduates [KQY202305]; Scientific Research and Innovation Project for Postgraduates of the Affiliated Stomatological Hospital of Chongqing Medical University
基金资助正文：This work was supported by Chongqing Postdoctoral Science Foundation (Grant No. CSTB2023NSCQ-BHX0111 to MG), Chongqing Traditional Chinese Medicine scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (Grant No. 2024ZYYB005 to HZ), the Natural Science Foundation of Chongqing (Grant No. cstc2021jcyj-msxmX0061 to ZT), the Chongqing Scientific Research and Innovation Project for Postgraduates (Grant No. CYS23348 to SR), the Scientific Research and Innovation Project for Postgraduates of the Affiliated Stomatological Hospital of Chongqing Medical University (Grant No. KQY202305 to SR).
