The association between diets and periodontitis: a bidirectional two-sample Mendelian randomization study

作者全名：Yang, Xiaoyu; Wang, Jingchan; Hong, Houlin; Feng, Xing; Zhang, Xiumei; Song, Jinlin

作者地址：[Yang, Xiaoyu; Wang, Jingchan; Feng, Xing; Song, Jinlin] Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China; [Yang, Xiaoyu; Wang, Jingchan; Feng, Xing; Song, Jinlin] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China; [Yang, Xiaoyu; Wang, Jingchan; Feng, Xing; Song, Jinlin] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China; [Hong, Houlin] CUNY, Grad Sch Publ Hlth & Hlth Policy, Dept Community Hlth & Social Sci, New York, NY USA; [Zhang, Xiumei] Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China

通信作者：Song, JL (通讯作者)，Chongqing Med Univ, Coll Stomatol, Chongqing, Peoples R China.; Song, JL (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing, Peoples R China.; Song, JL (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Chongqing, Peoples R China.; Zhang, XM (通讯作者)，Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China.

来源：FRONTIERS IN GENETICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:001245852300001

JCR分区：Q2

影响因子：2.8

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：periodontitis; dietary habits; dietary antioxidants; mendelian randomization; oral health

摘要：Background Periodontitis, a complex inflammatory condition, has been associated with dietary habits and antioxidants. While the association between certain dietary patterns and periodontitis has been documented, the bidirectional relationship remains unclear. This study utilizes Mendelian randomization (MR) analysis to investigate the bidirectional associations between dietary factors comprising dietary antioxidants, and periodontitis.Methods Employing a two-sample MR approach, this study analyzed genome-wide association study (GWAS) data on diets and periodontitis from large databases and published literature. Instrumental variables (IVs) were selected and filtered based on genetic variants associated with dietary factors and periodontitis, respectively. Various MR methods, including Inverse Variance Weighted, MR-Egger, Weighted Median, Weighted Mode, and Simple Mode were applied to assess the bidirectional associations. Sensitivity analyses were conducted to validate the robustness of the findings.Results Our analysis revealed significant associations between certain dietary factors and the risk of periodontitis. Specifically, higher intake of filtered coffee, low-calorie drinks, and other cereals, as well as increased metabolic circulating levels of gamma-tocopherol, were associated with an elevated risk of periodontitis. Conversely, consumption of cheese, white rice, chocolate bars, unsalted peanuts, and higher absolute circulating levels of vitamin C were linked to a reduced risk. Additionally, the study suggests that periodontitis may influence dietary habits, indicating a bidirectional relationship.Conclusion This study provides additional evidence of a bidirectional association between dietary factors and periodontitis. It highlights the importance of dietary interventions in the prevention and management of periodontitis. The findings underscore the need for incorporating dietary counseling into periodontal disease management protocols and suggest the potential of personalized dietary strategies for periodontitis patients. Further research is warranted to explore the mechanisms underlying these associations and to confirm these findings in diverse populations.

基金机构：National Natural Science Foundation of China [U22A20314]; National Key Research and Development Program of China [2022YFC2504200]

基金资助正文：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The financial support for this study was provided by grants from the National Natural Science Foundation of China (Grant Nos. U22A20314), and the National Key Research and Development Program of China (Grant No. 2022YFC2504200).