Patchy profile sign in RAPID software: a specific marker for intracranial atherosclerotic stenosis in acute ischemic stroke

作者全名：Zhang, Lingwen; Xue, Hua; Bu, Xiaoqing; Liao, Juan; Tang, Ge; Chen, Yu; Zhao, Libo; Yang, Deyu; Liu, Li; Liu, Shudong

作者地址：[Zhang, Lingwen; Xue, Hua; Tang, Ge; Chen, Yu; Zhao, Libo; Yang, Deyu; Liu, Shudong] Chongqing Med Univ, Dept Neurol, Yongchuan Hosp, Chongqing, Peoples R China; [Zhang, Lingwen; Xue, Hua; Liao, Juan; Tang, Ge; Chen, Yu; Zhao, Libo; Yang, Deyu; Liu, Li; Liu, Shudong] Chongqing Med Univ, Yongchuan Hosp, Chongqing Key Lab Cerebrovasc Dis Res, Dept Neurol, Chongqing 402160, Peoples R China; [Bu, Xiaoqing] Chongqing Med Univ, Sch Publ Hlth, Dept Epidemiol, Chongqing, Peoples R China; [Liu, Li] Chongqing Med Univ, Yongchuan Hosp, Dept Hlth Management, Chongqing 402160, Peoples R China

通信作者：Liu, SD (通讯作者)，Chongqing Med Univ, Dept Neurol, Yongchuan Hosp, Chongqing, Peoples R China.; Liu, SD (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Chongqing Key Lab Cerebrovasc Dis Res, Dept Neurol, Chongqing 402160, Peoples R China.

来源：FRONTIERS IN NEUROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001245972900001

JCR分区：Q2

影响因子：2.7

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：ischemic stroke; intracranial embolism; perfusion; software; atherosclerotic; computed tomography

摘要：Purpose: Identifying the etiology of acute ischemic stroke (AIS) before endovascular treatment (EVT) is important but challenging. In CT perfusion imaging processed by perfusion software, we observed a phenomenon called patchy profile sign (PPS), that is, the hypoperfusion morphology in RAPID software is a discontinuous sheet pattern. This phenomenon is predominantly observed in patients diagnosed with intracranial atherosclerotic stenosis (ICAS). The study intends to assess whether the PPS can be used to differentiate ICAS from intracranial embolism. Method: Patients with AIS due to M1 segment occlusion of the MCA who underwent mechanical thrombectomy were retrospectively enrolled. The receiver operating characteristic (ROC) curve analysis was performed to assess the value of PPS in predicting ICAS. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy of the PPS for prediction of ICAS were calculated. Results: A total of 51 patients were included in the study. The PPS was observed in 10 of 19 (52.6%) patients with ICAS, and in 2 of 32 (6.3%) patients with intracranial embolism (p < 0.001). Interobserver agreement for identifying PPS was excellent (kappa = 0.944). The sensitivity, specificity, PPV, NPV, and accuracy of the PPS for predicting ICAS were 52.6, 93.8, 83.3, 76.9, and 78.4%, respectively. Conclusion: The PPS on RAPID software is an imaging marker with high specificity for ICAS. Larger sample sizes are imperative to validate the findings.

基金机构：National Natural Science Foundation of China [81803309]; Chongqing Science and Health Joint Medical Research Project [2019QNXM014]; Public Welfare Science and Technology Projects of Yongchuan District in 2022 [2022yc-jckx20053]

基金资助正文：The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The study was supported by the National Natural Science Foundation of China [grant no. 81803309]; Chongqing Science and Health Joint Medical Research Project [grant no. 2019QNXM014]; and the Public Welfare Science and Technology Projects of Yongchuan District in 2022 [grant no. 2022yc-jckx20053].