Focus on brain-lung crosstalk: Preventing or treating the pathological vicious circle between the brain and the lung

作者全名：Li, Xiaoqiu; Deng, Jie; Long, Yu; Ma, Yin; Wu, Yuanyuan; Hu, Yue; He, Xiaofang; Yu, Shuang; Li, Dan; Li, Nan; He, Fei

作者地址：[Li, Xiaoqiu; Deng, Jie; Long, Yu; Ma, Yin; Wu, Yuanyuan; Hu, Yue; He, Xiaofang; Yu, Shuang; Li, Dan] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China; [He, Fei] Chongqing Med Univ, Yongchuan Hosp, Clin Coll 5, Dept Geratol, Chongqing 402160, Peoples R China; [Li, Nan] Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, 1166,Liutai Ave, Chengdu 611137, Peoples R China

通信作者：He, F (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Clin Coll 5, Dept Geratol, Chongqing 402160, Peoples R China.; Li, N (通讯作者)，Chengdu Univ Tradit Chinese Med, State Key Lab Southwestern Chinese Med Resources, 1166,Liutai Ave, Chengdu 611137, Peoples R China.

来源：NEUROCHEMISTRY INTERNATIONAL

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001246751900001

JCR分区：Q1

影响因子：4.4

年份：2024

卷号：178

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Brain -lung crosstalk; Lung -brain crosstalk; Complications; Mechanism; Secondary disease; Drug therapy

摘要：Recently, there has been increasing attention to bidirectional information exchange between the brain and lungs. Typical physiological data is communicated by channels like the circulation and sympathetic nervous system. However, communication between the brain and lungs can also occur in pathological conditions. Studies have shown that severe traumatic brain injury (TBI), cerebral hemorrhage, subarachnoid hemorrhage (SAH), and other brain diseases can lead to lung damage. Conversely, severe lung diseases such as acute respiratory distress syndrome (ARDS), pneumonia, and respiratory failure can exacerbate neuroinflammatory responses, aggravate brain damage, deteriorate neurological function, and result in poor prognosis. A brain or lung injury can have adverse effects on another organ through various pathways, including inflammation, immunity, oxidative stress, neurosecretory factors, microbiome and oxygen. Researchers have increasingly concentrated on possible links between the brain and lungs. However, there has been little attention given to how the interaction between the brain and lungs affects the development of brain or lung disorders, which can lead to clinical states that are susceptible to alterations and can directly affect treatment results. This review described the relationships between the brain and lung in both physiological and pathological conditions, detailing the various pathways of communication such as neurological, inflammatory, immunological, endocrine, and microbiological pathways. Meanwhile, this review provides a comprehensive summary of both pharmacological and non-pharmacological interventions for diseases related to the brain and lungs. It aims to support clinical endeavors in preventing and treating such ailments and serve as a reference for the development of relevant medications.

基金机构：Science & Technology Department of Sichuan Province [2022NSFSC1406]; Sichuan Provincial Administration of Traditional Chinese Medicine [2023MS467]; Enhancement Programs of Academic Talent Research of Xinglin Scholar of Chengdu University of Traditional Chinese Medicine [OJJJ2022014, XCZX2022007]; Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2022MSXM177]

基金资助正文：This study was supported by Science & Technology Department of Sichuan Province (NO: 2022NSFSC1406) ; Sichuan Provincial Administration of Traditional Chinese Medicine (NO: 2023MS467) ; the Enhancement Programs of Academic Talent Research of Xinglin Scholar of Chengdu University of Traditional Chinese Medicine (NO: OJJJ2022014, NO: XCZX2022007) ; Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) (NO: 2022MSXM177) .