Predictive significance of glycolysis-associated lncRNA profiles in colorectal cancer progression
作者全名：Mao, Rui; Xu, Chenxin; Zhang, Quanzheng; Wang, Zheng; Liu, Yanjun; Peng, Yurui; Li, Ming
作者地址：[Mao, Rui] Cent South Univ, Xiangya Hosp, Hunan Key Lab Aging Biol, Changsha, Peoples R China; [Xu, Chenxin; Liu, Yanjun; Peng, Yurui] Chongqing Med Univ, Affiliated Hosp Southwest Jiaotong Univ, Affiliated Hosp Chengdu 2,Ctr Gastrointestinal & M, Peoples Hosp Chengdu 3,Dept Gen Surg, 82 Qinglong Rd, Chengdu 610031, Sichuan, Peoples R China; [Xu, Chenxin; Liu, Yanjun; Peng, Yurui] Chongqing Med Univ, Affiliated Hosp Southwest Jiaotong Univ, Affiliated Hosp Chengdu 2,Dept Gen Surg, Peoples Hosp Chengdu 3,Ctr Obes & Metab Dis, Chengdu 610031, Peoples R China; [Zhang, Quanzheng] Chengdu Third Peoples Hosp, Dept Crit Care Med, Chengdu 610031, Peoples R China; [Wang, Zheng] Chinese Acad Med Sci & Peking Union Med Coll, Canc Hosp, Natl Clin Res Ctr Canc, Dept Colorectal Surg,Natl Canc Ctr, Beijing, Peoples R China; [Li, Ming] Chongqing Med Univ, Affiliated Hosp Southwest Jiaotong Univ, Affiliated Hosp Chengdu 2, Peoples Hosp Chengdu 3,Dept Hepatobiliary Surg, 82 Qinglong Rd, Chengdu 610031, Sichuan, Peoples R China
通信作者：Liu, YJ; Peng, YR (通讯作者)，Chongqing Med Univ, Affiliated Hosp Southwest Jiaotong Univ, Affiliated Hosp Chengdu 2,Ctr Gastrointestinal & M, Peoples Hosp Chengdu 3,Dept Gen Surg, 82 Qinglong Rd, Chengdu 610031, Sichuan, Peoples R China.; Liu, YJ; Peng, YR (通讯作者)，Chongqing Med Univ, Affiliated Hosp Southwest Jiaotong Univ, Affiliated Hosp Chengdu 2,Dept Gen Surg, Peoples Hosp Chengdu 3,Ctr Obes & Metab Dis, Chengdu 610031, Peoples R China.; Li, M (通讯作者)，Chongqing Med Univ, Affiliated Hosp Southwest Jiaotong Univ, Affiliated Hosp Chengdu 2, Peoples Hosp Chengdu 3,Dept Hepatobiliary Surg, 82 Qinglong Rd, Chengdu 610031, Sichuan, Peoples R China.
来源：BMC MEDICAL GENOMICS
ESI学科分类：MOLECULAR BIOLOGY & GENETICS
WOS号：WOS:001247408100001
JCR分区：Q3
影响因子：2.1
年份：2024
卷号：17
期号：1
开始页：
结束页：
文献类型：Article
关键词：Warburg effect; Colorectal cancer; lncRNA; Prognostic signature; Nomogram
摘要：Background The Warburg effect is a hallmark characteristic of colorectal cancer (CRC). Despite extensive research, the role of long non-coding RNAs (lncRNAs) in influencing the Warburg effect remains incompletely understood. Our study aims to identify lncRNAs that may modulate the Warburg effect by functioning as competing endogenous RNAs (ceRNAs).Methods Utilizing bioinformatics approaches, we extracted glycolysis-associated gene data from the Kyoto Encyclopedia of Genes and Genomes (KEGG) and identified 101 glycolysis-related lncRNAs in CRC. We employed Univariable Cox regression, Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis, and Multivariable Cox regression to develop a prognostic model comprising four glycolysis-linked lncRNAs. We then constructed a prognostic nomogram integrating this lncRNA model with other relevant clinical parameters.Results The prognostic efficacy of our four-lncRNA signature and its associated nomogram was validated in both training and validation cohorts. Functional assays demonstrated significant glycolysis and hexokinase II (HK2) inhibition following the silencing of RUNDC3A - AS1, a key lncRNA in our prognostic signature, highlighting its regulatory importance in the Warburg effect.Conclusions Our research illuminates the critical role of glycolysis-centric lncRNAs in CRC. The developed prognostic model and nomogram underscore the pivotal prognostic and regulatory significance of the lncRNA RUNDC3A - AS1 in the Warburg effect in colorectal cancer.
基金机构：National Natural Science Foundation of China [81502075]; Foundation of Science and Technology of Sichuan Province [2021YFS0101]
基金资助正文：This study was supported by the National Natural Science Foundation of China (81502075) and the Foundation of Science and Technology of Sichuan Province (2021YFS0101).
