Nomogram and calculator for predicting the prognosis of patients with giant hepatocellular carcinoma

作者全名："Chen, Wanjin; Cheng, Shengtao"

作者地址："[Chen, Wanjin] Chongqing Med Univ, Coll Lab Med, Key Lab Clin Lab Diagnost, Minist Educ, Chongqing, Peoples R China; [Chen, Wanjin; Cheng, Shengtao] Chongqing Med Univ, Key Lab Mol Biol Infect Dis Designated Chinese Mi, Chongqing, Peoples R China"

通信作者："Cheng, ST (通讯作者)，Chongqing Med Univ, Key Lab Mol Biol Infect Dis Designated Chinese Mi, Chongqing, Peoples R China."

来源：EXPERT REVIEW OF ANTICANCER THERAPY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001249007200001

JCR分区：Q3

影响因子：3.3

年份：2024

卷号：24

期号：8

开始页：781

结束页：788

文献类型：Article

关键词：Giant hepatocellular carcinoma; overall survival; nomogram; SEER; calculator

摘要："ObjectivesThis study aimed to explore the factors affecting the overall survival (OS) of giant hepatocellular carcinoma (G-HCC) patients and establish a nomogram and an Internet-based OS calculator for evaluating the OS of G-HCC patients.Research design and methodsA total of 2445 G-HCC patients were searched in the SEER database. The independent variables affecting OS of G-HCC patients were determined by univariate and multivariate analyses, and a nomogram and Internet-based OS calculator were established. The accuracy of the nomogram was evaluated by the C-index, the AUC curve, and calibration curve.ResultsGrade, surgery, radiotherapy, chemotherapy, T-staging, M-staging, AFP, and fibrosis were identified as independent variables affecting OS. These variables were included in the nomogram model and Internet-based OS calculator to evaluate OS in G-HCC patients. The C-indices and AUC of the nomogram are better than AJCC-staging system. Similarly, the calibration curves revealed that the actual survival was consistent with nomogram-based survival.ConclusionThe nomogram and Internet-based OS calculator are superior to the traditional AJCC-staging system in the reliability and convenience of prognosis assessment for G-HCC patients, which is more conducive for clinicians to predict the survival of G-HCC patients and make the best treatment strategy."

基金机构：Scientific and Technological Research Program of Chongqing Municipal Education Commission [KJQN202300465]

基金资助正文：This work was funded by Scientific and Technological Research Program of Chongqing Municipal Education Commission (KJQN202300465 to STC).