Metabolic features of adolescent major depressive disorder: A comparative study between treatment-resistant depression and first-episode drug-naive depression

作者全名：Gan, Xieyu; Li, Xuemei; Cai, Yuping; Yin, Bangmin; Pan, Qiyuan; Teng, Teng; He, Yuqian; Tang, Han; Wang, Ting; Li, Jie; Zhu, Zhengjiang; Zhou, Xinyu; Li, Jinfang

作者地址：[Gan, Xieyu; Tang, Han; Li, Jinfang] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China; [Li, Xuemei; Yin, Bangmin; Teng, Teng; He, Yuqian; Li, Jie; Zhou, Xinyu] Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China; [Cai, Yuping; Zhu, Zhengjiang] Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai Inst Organ Chem, Shanghai, Peoples R China; [Pan, Qiyuan] First Peoples Hosp Zaoyang City, Xiangyang, Hubei, Peoples R China; [Wang, Ting] Chongqing Med Univ, Dept Psychol, Affiliated Hosp 2, Chongqing, Peoples R China; [Zhu, Zhengjiang] Shanghai Key Lab Aging Studies, Shanghai, Peoples R China

通信作者：Li, JF (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 2, Chongqing, Peoples R China.; Zhou, XY (通讯作者)，Chongqing Med Univ, Dept Psychiat, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhu, ZJ (通讯作者)，Chinese Acad Sci, Interdisciplinary Res Ctr Biol & Chem, Shanghai Inst Organ Chem, Shanghai, Peoples R China.

来源：PSYCHONEUROENDOCRINOLOGY

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:001249877000001

JCR分区：Q2

影响因子：3.4

年份：2024

卷号：167

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Adolescent major depressive disorder; Treatment-resistant depression; Metabolomic; Tyrosine metabolism; Glycerophospholipid metabolism

摘要：Major depressive disorder (MDD) is a psychiatric illness that can jeopardize the normal growth and development of adolescents. Approximately 40% of adolescent patients with MDD exhibit resistance to conventional antidepressants, leading to the development of Treatment-Resistant Depression (TRD). TRD is associated with severe impairments in social functioning and learning ability and an elevated risk of suicide, thereby imposing an additional societal burden. In this study, we conducted plasma metabolomic analysis on 53 adolescents diagnosed with first-episode drug-na & iuml;ve MDD (FEDN-MDD), 53 adolescents with TRD, and 56 healthy controls (HCs) using hydrophilic interaction liquid chromatography-mass spectrometry (HILIC-MS) and reversed-phase liquid chromatography-mass spectrometry (RPLC-MS). We established a diagnostic model by identifying differentially expressed metabolites and applying cluster analysis, metabolic pathway analysis, and multivariate linear support vector machine (SVM) algorithms. Our findings suggest that adolescent TRD shares similarities with FEDN-MDD in five amino acid metabolic pathways and exhibits distinct metabolic characteristics, particularly tyrosine and glycerophospholipid metabolism. Furthermore, through multivariate receiver operating characteristic (ROC) analysis, we optimized the area under the curve (AUC) and achieved the highest predictive accuracy, obtaining an AUC of 0.903 when comparing FEDN-MDD patients with HCs and an AUC of 0.968 when comparing TRD patients with HCs. This study provides new evidence for the identification of adolescent TRD and sheds light on different pathophysiologies by delineating the distinct plasma metabolic profiles of adolescent TRD and FEDNMDD.

基金机构：STI2030-Major Projects [2022ZD0212900]; National Natural Science Foundation of China [82271565, 22022411]; National Key R & D Program of China [2022YFC3400700]; Shanghai Municipal Science and Technology Major Project [2019SHZDZX02]; Shanghai Municipal Science and Technology Major Project (CEMS, CAS)

基金资助正文：This work was supported by STI2030-Major Projects (2022ZD0212900) , National Natural Science Foundation of China (82271565) , National Key R & D Program of China (2022YFC3400700) , National Natural Science Foundation of China (22022411) , Shanghai Municipal Science and Technology Major Project (2019SHZDZX02) , and Shanghai Municipal Science and Technology Major Project (CEMS, CAS) .