Prussian blue nanoparticles coated with tumor cell membranes for precise photothermal therapy and subsequent inflammation reduction

作者全名：Zou, Hairong; Wang, Hui; Zhong, Yu; Zhang, Zhijun; Wang, Zhigang; Shang, Tingting

作者地址：[Zou, Hairong; Wang, Zhigang; Shang, Tingting] Chongqing Med Univ, Inst Ultrasound Imaging, Affiliated Hosp 2, Dept Ultrasound, 76 Linjiang Rd, Chongqing 400010, Peoples R China; [Zou, Hairong; Wang, Hui; Zhong, Yu; Zhang, Zhijun] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 4, 55 Daxuecheng Middle Rd, Chongqing 400131, Peoples R China

通信作者：Shang, TT (通讯作者)，Chongqing Med Univ, Inst Ultrasound Imaging, Affiliated Hosp 2, Dept Ultrasound, 76 Linjiang Rd, Chongqing 400010, Peoples R China.

来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:001249890800001

JCR分区：Q3

影响因子：2.5

年份：2024

卷号：723

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Prussian blue; Cell membrane-coated nanoparticles; Photothermal therapy; Anti-inflammatory effect

摘要：The utilization of photothermal agents (PTAs) in photothermal therapy (PTT) is faced with challenges such as immune clearance and inadequate concentration, which consequently result in residual tumors and an increased risk of recurrence and metastasis. Conversely, excessive treatment can lead to heightened inflammation and inevitable harm to adjacent healthy tissues. To address these issues, we developed a nanosystem (M@PB) consisting of Prussian blue coated with tumor cell membrane for precise photothermal therapy (PTT) and subsequent reduction of inflammation. This system not only evades immune attack due to the homologous biological characteristics of the encapsulating cell membrane but also exhibits active targeting capabilities towards homologous tumors. Furthermore, it effectively reduces excessive phototoxicity by leveraging the distinctive photothermal and anti-inflammatory characteristics of PB nanoparticles. The resulting M@PB nanosystem demonstrates effective photothermal ablation under 808 nm laser irradiation while mitigating the inflammatory response through inhibiting of local production of inflammatory mediators. Our study provides valuable insights into achieving targeted PTT with high efficiency while minimizing post-treatment inflammatory responses.

基金机构：Natural Science Foundation of Chongqing [CSTB2022NSCQ-MSX0777]

基金资助正文：This work was supported by the Natural Science Foundation of Chongqing (CSTB2022NSCQ-MSX0777) , China.