Association between triglyceride glucose index and breast cancer in 142,184 Chinese adults: findings from the REACTION study

作者全名：Wu, Xueyan; Wang, Shuangyuan; Lin, Lin; Jia, Xiaojing; Hu, Chunyan; Qi, Hongyan; Lin, Hong; Zheng, Ruizhi; Li, Mian; Xu, Yu; Xu, Min; Chen, Lulu; Zeng, Tianshu; Hu, Ruying; Ye, Zhen; Shi, Lixin; Su, Qing; Yu, Xuefeng; Yan, Li; Wang, Tiange; Zhao, Zhiyun; Zheng, Jie; Qin, Guijun; Wan, Qin; Chen, Gang; Dai, Meng; Tang, Xulei; Gao, Zhengnan; Shen, Feixia; Gu, Xuejiang; Luo, Zuojie; Qin, Yingfen; Chen, Li; Hou, Xinguo; Huo, Yanan; Li, Qiang; Wang, Guixia; Zhang, Yinfei; Liu, Chao; Wang, Youmin; Wu, Shengli; Yang, Tao; Deng, Huacong; Zhao, Jiajun; Mu, Yiming; Ning, Guang; Wang, Weiqing; Bi, Yufang; Chen, Yuhong; Lu, Jieli

作者地址：[Wu, Xueyan; Wang, Shuangyuan; Lin, Lin; Jia, Xiaojing; Hu, Chunyan; Qi, Hongyan; Lin, Hong; Zheng, Ruizhi; Li, Mian; Xu, Yu; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Zheng, Jie; Dai, Meng; Ning, Guang; Wang, Weiqing; Bi, Yufang; Chen, Yuhong; Lu, Jieli] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China; [Wu, Xueyan; Wang, Shuangyuan; Lin, Lin; Jia, Xiaojing; Hu, Chunyan; Qi, Hongyan; Lin, Hong; Zheng, Ruizhi; Li, Mian; Xu, Yu; Xu, Min; Wang, Tiange; Zhao, Zhiyun; Zheng, Jie; Dai, Meng; Ning, Guang; Wang, Weiqing; Bi, Yufang; Chen, Yuhong; Lu, Jieli] Shanghai Jiao Tong Univ, Key Lab Endocrine & Metab Dis, Shanghai Natl Clin Res Ctr Metab Dis,Natl Hlth Com, Shanghai Natl Ctr Translat Med,Ruijin Hosp,Sch Med, Shanghai, Peoples R China; [Chen, Lulu; Zeng, Tianshu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan, Peoples R China; [Hu, Ruying; Ye, Zhen] Inst Chron Dis, Zhejiang Prov Ctr Dis Control & Prevent, Hangzhou, Peoples R China; [Shi, Lixin] Guiyang Med Coll, Dept Endocrinol, Affiliated Hosp, Guiyang, Peoples R China; [Su, Qing] Shanghai Jiaotong Univ SJTU, Sch Med, Xinhua Hosp, Shanghai, Peoples R China; [Yu, Xuefeng] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Wuhan, Peoples R China; [Yan, Li] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China; [Qin, Guijun] Zhengzhou Univ, Dept Endocrinol, Affiliated Hosp 1, Zhengzhou, Peoples R China; [Wan, Qin] Southwest Med Univ, Affiliated Hosp, Dept Endocrinol, Luzhou, Peoples R China; [Chen, Gang] Fujian Med Univ, Fujian Prov Hosp, Fuzhou, Peoples R China; [Tang, Xulei] Lanzhou Univ, Dept Endocrinol, Hosp 1, Lanzhou, Peoples R China; [Gao, Zhengnan] Dalian Municipal Cent Hosp, Dept Endocrinol, Dalian, Peoples R China; [Shen, Feixia; Gu, Xuejiang] Wenzhou Med Univ, Dept Endocrinol, Affiliated Hosp 1, Wenzhou, Peoples R China; [Luo, Zuojie; Qin, Yingfen] Guangxi Med Univ, Dept Endocrinol, Affiliated Hosp 1, Nanning, Peoples R China; [Chen, Li; Hou, Xinguo] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan, Peoples R China; [Huo, Yanan] Nanchang Univ, Dept Endocrinol, Jiangxi Prov Peoples Hosp, Nanchang, Peoples R China; [Li, Qiang] Harbin Med Univ, Dept Endocrinol, Affiliated Hosp 2, Harbin, Peoples R China; [Wang, Guixia] First Hosp Jilin Univ, Dept Endocrinol, Changchun, Peoples R China; [Zhang, Yinfei] Cent Hosp Shanghai Jiading Dist, Dept Endocrinol, Shanghai, Peoples R China; [Liu, Chao] Jiangsu Prov Hosp Integrat Chinese & Western Med, Dept Endocrinol, Nanjing, Peoples R China; [Wang, Youmin] Anhui Med Univ, Dept Endocrinol, Affiliated Hosp 1, Hefei, Peoples R China; [Wu, Shengli] Karamay Municipal Peoples Hosp, Dept Endocrinol, Karamay, Xinjiang, Peoples R China; [Yang, Tao] Nanjing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Nanjing, Peoples R China; [Deng, Huacong] Chongqing Med Univ, Dept Endocrinol, Affiliated Hosp 1, Chongqing, Peoples R China; [Zhao, Jiajun] Shandong Univ, Dept Endocrinol, Shandong Prov Hosp, Jinan, Peoples R China; [Mu, Yiming] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China

通信作者：Bi, YF; Chen, YH; Lu, JL (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China.; Bi, YF; Chen, YH; Lu, JL (通讯作者)，Shanghai Jiao Tong Univ, Key Lab Endocrine & Metab Dis, Shanghai Natl Clin Res Ctr Metab Dis,Natl Hlth Com, Shanghai Natl Ctr Translat Med,Ruijin Hosp,Sch Med, Shanghai, Peoples R China.

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001250003600001

JCR分区：Q2

影响因子：3.9

年份：2024

卷号：15

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：insulin resistance; triglyceride; glucose; breast cancer; Chinese population

摘要：Background The triglyceride glucose (TyG) index has been associated with an increased risk in breast cancer. However, this association remains unclear among the Chinese population. This study aimed to investigate whether the TyG index is associated with the risk of prevalent breast cancer in Chinese women.Methods This cross-sectional study included 142,184 women from the REACTION (Risk Evaluation of Cancers in Chinese Diabetic Individuals: A Longitudinal) Study, which recruited adults aged 40 years or older from 25 centers across mainland China between 2011 and 2012. The TyG index was calculated according to the formula: Ln (fasting triglycerides [mg/dL] x fasting glucose [mg/dL]/2). Multivariable-adjusted logistic regression models were used to evaluate odds ratios (ORs) and 95% confidence intervals (CIs) regarding the associations between the TyG index and breast cancer.Results Multivariable-adjusted logistic regression analysis showed that compared with the lowest quartile of the TyG index, the highest quartile of the TyG index was significantly associated with an increased risk of prevalent breast cancer, with an OR (95% CI) of 1.61 (1.19-2.17). In the stratified analysis, the association of each 1 SD increase in the TyG index with risk of prevalent breast cancer was more dominant in individuals with menarche at age 13-17, those who were postmenopausal, those with a history of breastfeeding, and those who had two to four children, with the ORs (95% CIs) of 1.35 (1.09-1.68), 1.27 (1.05-1.54), 1.26 (1.05-1.52), and 1.32 (1.08-1.62), respectively. Moreover, among those without discernible insulin resistance (homeostatic model assessment-insulin resistance [HOMA-IR] >= 2.5), hyperglycemia and dyslipidemia, each 1 SD increase in the TyG index was associated with a 1.36-fold increase in breast cancer risk, with an OR (95% CI) of 2.36 (1.44-3.87).Conclusion The TyG index is significantly associated with the prevalent breast cancer risk among middle-aged and elderly Chinese women.

基金机构：Ministry of Science and Technology of the People's Republic of China [2022YFC2505202, 2023YFC2506704]; National Natural Science Foundation of China [82370810, 91857205, 82088102, 82170819, 82372347, 82200998]; Science and Technology Committee of Shanghai [22Y31900300, 23JS1400900, 23Y11908400]; Clinical Research Project of Shanghai Municipal Health Commission [20224Y0087, 20214Y0002]; Shanghai Committee of Science and Technology, and Innovative Research Team of High-Level Local Universities in Shanghai

基金资助正文：The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This study was supported by the Ministry of Science and Technology of the People's Republic of China (Grant No. 2022YFC2505202 and 2023YFC2506704), the National Natural Science Foundation of China (Grant No. 82370810, 91857205, 82088102, 82170819, 82372347 and 82200998), Science and Technology Committee of Shanghai (Grant No. 22Y31900300, 23JS1400900 and 23Y11908400), Clinical Research Project of Shanghai Municipal Health Commission (Grant No. 20224Y0087 and 20214Y0002), Shanghai Committee of Science and Technology, and Innovative Research Team of High-Level Local Universities in Shanghai.