Effects of DASH diet with or without time-restricted eating in the management of stage 1 primary hypertension: a randomized controlled trial

作者全名：Zhou, Xiaoxin; Lin, Xiaoqian; Yu, Jing; Yang, Yi; Muzammel, Hira; Amissi, Said; Schini-Kerth, Valerie B.; Lei, Xun; Jose, Pedro A.; Yang, Jian; Shi, Dan

作者地址：[Zhou, Xiaoxin; Lin, Xiaoqian; Yang, Jian] Chongqing Med Univ, Res Ctr Metab & Cardiovasc Dis, Affiliated Hosp 3, Chongqing, Peoples R China; [Zhou, Xiaoxin; Lin, Xiaoqian; Yang, Jian] Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 3, Chongqing, Peoples R China; [Zhou, Xiaoxin; Muzammel, Hira; Amissi, Said; Schini-Kerth, Valerie B.] Univ Strasbourg, Fac Pharm, Translat CardioVasc Med, UR 3074, Strasbourg, France; [Yu, Jing; Shi, Dan] Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Chongqing, Peoples R China; [Yu, Jing; Shi, Dan] Chongqing Med Univ, Res Ctr Environm & Human Hlth, Sch Publ Hlth, Chongqing, Peoples R China; [Yang, Yi] Chongqing Med Univ, Dept Logist Management Div, Chongqing, Peoples R China; [Lei, Xun] Chongqing Med Univ, Res Ctr Med & Social Dev, Collaborat Innovat Ctr Social Risks Governance Hlt, Sch Publ Hlth, Chongqing, Peoples R China; [Jose, Pedro A.] George Washington Univ, Sch Med & Hlth Sci, Dept Med, Washington, DC USA; [Jose, Pedro A.] George Washington Univ, Sch Med & Hlth Sci, Dept Physiol & Pharmacol, Div Renal Dis & Hypertens, Washington, DC USA

通信作者：Yang, J (通讯作者)，Chongqing Med Univ, Res Ctr Metab & Cardiovasc Dis, Affiliated Hosp 3, Chongqing, Peoples R China.; Yang, J (通讯作者)，Chongqing Med Univ, Dept Clin Nutr, Affiliated Hosp 3, Chongqing, Peoples R China.; Shi, D (通讯作者)，Chongqing Med Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Chongqing, Peoples R China.; Shi, D (通讯作者)，Chongqing Med Univ, Res Ctr Environm & Human Hlth, Sch Publ Hlth, Chongqing, Peoples R China.

来源：NUTRITION JOURNAL

ESI学科分类：AGRICULTURAL SCIENCES

WOS号：WOS:001250036500001

JCR分区：Q1

影响因子：4.4

年份：2024

卷号：23

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Time-restricted eating; Primary hypertension; Urinary Na+ excretion; Blood pressure

摘要：Background Time-restricted eating (TRE), a popular form of intermittent fasting, has shown benefits for improving metabolic diseases and cardiometabolic health. However, the effect of TRE in the regulation of blood pressure in primary hypertension remains unclear. Methods A 6-week randomized controlled trial was conducted, in which a total of 74 stage 1 primary hypertensive patients without high-risk were randomly assigned to Dietary Approaches to Stop Hypertension (DASH) group (n = 37) or DASH + TRE group (n = 37). Participants in the DASH + TRE group were instructed to consume their food within an 8-h window. Scientific research platform in We Chat application was used to track participants. The primary outcome was blood pressure. The secondary outcomes included body composition, cardiometabolic risk factors, inflammation-related parameters, urinary Na+ excretion, other clinical variables and safety outcomes. Results The reduction of systolic blood pressure and diastolic blood pressure were 5.595 +/- 4.072 and 5.351 +/- 5.643 mm Hg in the DASH group and 8.459 +/- 4.260 and 9.459 +/- 4.375 mm Hg in the DASH + TRE group. DASH + TRE group improved blood pressure diurnal rhythm. Subjects in DASH + TRE group had decreased extracellular water and increased urinary Na+ excretion. Furthermore, the decrease in blood pressure was associated with a reduction of extracellular water or increase in urinary Na+ excretion. In addition, safety outcomes such as nighttime hunger were also reported. Conclusion Our study demonstrated that 8-h TRE + DASH diet caused a greater decrease in blood pressure in stage 1 primary hypertensive patients than DASH diet. This study may provide novel insights into the benefits of lifestyle modification in the treatment of primary hypertension.

基金机构：Scientific Research Innovation Project for Postgraduate in Chongqing; Chongqing Medical University, Chongqing, China

基金资助正文：We thank all the trial staff and trial participants, three interns Le Ma, Han Yang, Geng Zou from Department of Clinical Nutrition, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China; Yu Zhang, Hongli Zhou, Yaoyao Zhou, Yaxuan Zhao, Yuzhu Zhang, Jingwen Zhao, Tiecheng Huang, Yixin Zhong, Zhenxing Wang and Zhangding Hu from Department of Nutrition and Food Hygiene, School of Public Health, Chongqing Medical University, Chongqing, China; as well as nutritionist Bo Liu at Zhejiang Nutriease Co., Ltd., China. And we deeply thank others who gave us any help.