Impact of BSA and Au<SUP>3+</SUP> concentration on the formation and fluorescence properties of Au nanoclusters

作者全名：Li, Tao; Li, Zhuo; Chen, Fengjiao; Zhu, Liying; Tang, Hua; Wang, Dan; Tang, Zhenrong

作者地址：[Li, Tao; Li, Zhuo; Tang, Hua] Chongqing Med Univ, Key Lab Mol Biol Infect Dis, Minist Educ, Chongqing, Peoples R China; [Chen, Fengjiao] Chongqing Med Univ, Affiliated Hosp 1, Dept Clin Lab, Chongqing, Peoples R China; [Zhu, Liying] Guizhou Med Univ, Affiliated Hosp, Ctr Clin Labs, Guiyang, Peoples R China; [Wang, Dan] Peoples Hosp Rongchang Dist, Postdoctoral Res Ctr, Chongqing, Peoples R China; [Tang, Zhenrong] Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing, Peoples R China

通信作者：Wang, D (通讯作者)，Peoples Hosp Rongchang Dist, Postdoctoral Res Ctr, Chongqing, Peoples R China.; Tang, ZR (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Breast & Thyroid Surg, Chongqing, Peoples R China.

来源：RSC ADVANCES

ESI学科分类：CHEMISTRY

WOS号：WOS:001250316400001

JCR分区：Q2

影响因子：3.9

年份：2024

卷号：14

期号：27

开始页：19284

结束页：19293

文献类型：Article

关键词：　

摘要：Bovine serum albumin-stabilized Au nanoclusters (BSA-Au NCs) have emerged as promising contenders for imaging agents and highly sensitive fluorescence sensors due to their biocompatibility and strong photoluminescence. Optimizing the synthesis conditions of BSA-Au NCs is crucial for enhancing fluorescence imaging and other nanocluster applications. In this study, for the first time, we systematically investigated the effects of BSA concentration and Au3+ on both particle size and optical characteristics of BSA-Au NCs. When the two components achieved a suitable concentration ratio, it was beneficial to form BSA-Au NCs with a high quantum yield (QY = 74.30%) and good fluorescence stability. In contrast, an inappropriate concentration ratio would lead to the formation of gold nanoparticles (Au NPs), and their internal filtration effect (IFE) would attenuate the fluorescence emission of BSA-Au NCs. The BSA-Au NCs were then employed as efficient fluorescence sensors for detecting Hg2+. Furthermore, the growth mechanism of BSA-Au NCs was elucidated by monitoring fluorescence changes during different incubation times. The BSA-Au NCs with a high quantum yield introduce a novel synthetic concept for sensitive fluorescent probes and expanding versatile applications of BSA-Au NCs in catalysis, chemical sensing and biomedicine.

基金机构：China Postdoctoral Science Foundation [2023MD734126]; China Postdoctoral Science Foundation [2022CQBSHTB3003]; Chongqing Municipal Postdoctoral Science Special Foundation [2023RCMSXM007]; Chongqing Rongchang Medical Scientific Research Project

基金资助正文：This study was supported by the project funded by China Postdoctoral Science Foundation (2023MD734126), Chongqing Municipal Postdoctoral Science Special Foundation (2022CQBSHTB3003) and Chongqing Rongchang Medical Scientific Research Project (2023RCMSXM007). We would like to express our gratitude to all those who supported the subject.