The outcome and related risk factors of unvaccinated patients with end-stage kidney disease during the Omicron pandemic: a multicentre retrospective study

作者全名：Zhang, Quanchao; Lu, Caibao; Wu, Shaofa; He, Jin; Wang, Han; Li, Jie; Wu, Zhifen; Ta, Bingshuang; Yang, Bingfeng; Liao, Shengli; Wang, Liao; Chen, Hongwei; Li, Moqi; He, Wenchang; Wang, Yiqin; Jiang, Lili; Zhao, Jing-Hong; Nie, Ling

作者地址：[Zhang, Quanchao; Lu, Caibao; Chen, Hongwei; Li, Moqi; He, Wenchang; Wang, Yiqin; Zhao, Jing-Hong; Nie, Ling] Third Mil Med Univ, Chongqing Clin Res Ctr Kidney & Urol Dis, Key Lab Prevent & Treatment Chron Kidney Dis Chong, Dept Nephrol,Xinqiao Hosp,Army Med Univ, Chongqing, Peoples R China; [Wu, Shaofa; Jiang, Lili] Youyang Hosp, Dept Nephrol, Chongqing, Peoples R China; [He, Jin; Wang, Han] Chonggang Gen Hosp, Dept Endocrinol & Nephrol, Chongqing, Peoples R China; [Li, Jie; Wu, Zhifen] Yongchuan Peoples Hosp Chongqing, Urol & Kidney Dis Ctr, Chongqing, Peoples R China; [Ta, Bingshuang; Yang, Bingfeng] Chong Qing Bishan Dist Hosp Tradit Chinese Med, Dept Nephrol & Endocrinol, Chongqing, Peoples R China; [Liao, Shengli; Wang, Liao] Nanchuan Hosp Tradit Chinese Med, Hemodialysis Ctr, Chongqing, Peoples R China

通信作者：Zhao, JH; Nie, L (通讯作者)，Third Mil Med Univ, Chongqing Clin Res Ctr Kidney & Urol Dis, Key Lab Prevent & Treatment Chron Kidney Dis Chong, Dept Nephrol,Xinqiao Hosp,Army Med Univ, Chongqing, Peoples R China.; Jiang, LL (通讯作者)，Youyang Hosp, Dept Nephrol, Chongqing, Peoples R China.

来源：BMJ OPEN

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:001250370500007

JCR分区：Q1

影响因子：2.4

年份：2024

卷号：14

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：Dialysis; Mortality; Vaccination

摘要：Objectives The study aims to identify the outcome and the related factors of unvaccinated patients with end-stage kidney disease during the Omicron pandemic.Design A multicentre retrospective study of patients with end-stage kidney disease undergone maintenance haemodialysis (HD) in China.Setting 6 HD centres in China.Participants A total of 654 HD patients who tested positive for SARS-CoV-2 were ultimately included in the study.Outcome measures The primary outcomes of interest were adverse outcomes, including hospitalisation due to COVID-19 and all-cause mortality.Results The average age of the patients was 57 years, with 33.6% of them being over 65 years. Among the patients, 57.5% were male. During the follow-up period, 158 patients (24.2%) experienced adverse outcomes, and 93 patients (14.2%) died. The majority of patients (88/158) developed adverse outcomes within 30 days, and most deaths (77/93) occurred within 1 month. An advanced multivariable Cox regression analysis identified that adverse outcomes were associated with various factors while all-cause mortality was related to advanced age, male gender, high levels of C reactive protein (CRP) and low levels of prealbumin. The Kaplan-Meier curves demonstrated significantly higher all-cause mortality rates in the older, male, high CRP and low prealbumin subgroups.Conclusions Among unvaccinated HD patients with confirmed Omicron infections, various factors were found to be linked to adverse outcomes. Notably, age, sex, CRP and prealbumin had a substantial impact on the risk of all-cause mortality.

基金机构：National Natural Science Foundation of China [82101967]

基金资助正文：This work was supported by grants from the National Natural Science Foundation of China (NO. 82101967).